Caffeine

ALX-550-322

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CNS stimulant

CNS stimulant. Blocks adenosine A1 and A2A receptors. cAMP phosphodiesterase inhibitor. Interferes with the uptake and storage of Ca2+ by the sarcoplasmic reticulum in skeletal muscle. Prevents apoptosis and cell cycle effects induced by various chemicals. Inhibits cellular DNA repair mechanisms. Anti-inflammatory.

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Product Details

Alternative Name	1,3,7-Trimethylxanthine, 3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
Appearance	White to colorless powder.
CAS	58-08-2
Couple Target	Adenosine receptor, PDE
Couple Type	Blocker, Inhibitor
Formula	C₈H₁₀N₄O₂
Identity	Determined by IR.
MI	14: 1636
MW	194.2
Purity	≥99% (HPLC)
Solubility	Soluble in chloroform, 100% alcohol or hot water.
Source	Found in tea leaves, coffee beans, cocoa beans, maté leaves, guarana paste and kola nuts.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

New insights into the influences of baking and storage on the nonvolatile compounds in oolong tea: A nontargeted and targeted metabolomics study: J. Peng, et al.; Food Chem. 375, 131872 (2022), Abstract
A comprehensive study of the differences in protein expression and chemical constituents in tea leaves (Camellia sinensis var. sinensis) with different maturity using a combined proteomics and metabolomics method: Z. Sun, et al.; Food Res. Int. 157, 111397 (2022), Abstract
Impact of Various Microbial-Fermented Methods on the Chemical Profile of Dark Tea Using a Single Raw Tea Material: J. Shi, et al.; J. Agric. Food Chem. 69, 4210 (2021), Abstract
Time effect of rutaecarpine on caffeine pharmacokinetics in rats: R.K. Estari, et al.; Biochem. Biophys. Rep. 28, 101121 (2021), Abstract
Study of the dynamic changes in the Non-volatile chemical constituents of black tea during fermentation processing by a Non-targeted metabolomics approach: J. Tan, et al.; Food Res. Int. 79, 106 (2016)
Baculoviruses modulate a proapoptotic DNA damage response to promote virus multiplication: Mitchell, J. K., Friesen, P. D., et al.; J. Virol. 86, 13542 (2012), Abstract
The enigmatic effects of caffeine in cell cycle and cancer: A. M. & Bode and Z. Dong; Cancer Lett. 247, 26 (2007), (Review), Abstract
Immunomodulatory effects of caffeine: friend or foe: L. A. Horrigan, et al.; Pharmacol. Ther. 111, 877 (2006), (Review), Abstract
Novel neuroprotection by caffeine and adenosine A(2A) receptor antagonists in animal models of Parkinson’s disease: A. Kalda, et al.; J. Neurol. Sci. 248, 9 (2006), (Review), Abstract
Acute effects of caffeine on arterial stiffness, wave reflections, and central aortic pressures: T.G. Papaioannou, et al.; Am. J. Hypertens. 18, 129 (2005), (Review), Abstract

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Last modified: May 29, 2024

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Caffeine

ALX-550-322

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