(+)-Bicuculline

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GABA_A receptor antagonist

GABA_A receptor antagonist.

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Alternative Name	D-Bicuculline
Appearance	Off-white to yellow powder.
CAS	485-49-4
Couple Target	GABA receptor
Couple Type	Inhibitor, Ligand
Formula	C₂₀H₁₇NO₆
MI	14: 1203
MW	367.4
Purity	≥98% (HPLC)
RTECS	LV0909840
Solubility	Soluble in benzene, chloroform or ethyl acetate.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Amyloid β oligomers disrupt piriform cortical output via a serotonergic pathway: X. Wang, et al.; Neurobiol- Aging 121, 64 (2023), Abstract
Brain-enriched RagB isoforms regulate the dynamics of mTORC1 activity through GATOR1 inhibition: G. Figlia, et al.; Nat. Cell Biol. 24, 1407 (2022), Abstract
Nuclear calcium signaling induces expression of the synaptic organizers lrrtm1 and lrrtm2: S.N. Hayer, et al.; J. Biol. Chem. 290, 5523 (2015), Application(s): Cell Culture, Abstract — Full Text
Dysfunctional astrocytic and synaptic regulation of hypothalamic glutamatergic transmission in a mouse model of early-life adversity: relevance to neurosteroids and programming of the stress response: Gunn, B. G., Cunningham, L., et al.; J. Neurosci. 33, 19534 (2013), Abstract
Synaptic NMDA Receptor Activation Stimulates α-Secretase Amyloid Precursor Protein Processing and Inhibits Amyloid-β Production: Sarah E. Hoey, et al.; J. Neurosci. 29, 4442 (2009), Abstract
Convulsant bicuculline modifies CNS muscarinic receptor affinity: P.G. Schneider and G. Rodriguez de Lores Arnaiz; BMC Neurosci. 7, 32 (2006), Abstract — Full Text
Cannabinoid suppressed bicuculline-induced convulsion without respiratory depression in the brainstem-spinal cord preparation from newborn rats: S. Koda, et al.; Biomed. Res. 26, 241 (2005), Abstract — Full Text

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