Z-Phe-Tyr(tBu)-diazomethylketone

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Cathepsin-L inhibitor

Irreversible inhibitor of cathepsin L.

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Alternative Name	Z-FY(tBu)-DMK
Appearance	White to off-white powder.
Formula	C₃₁H₃₄N₄O₅
MW	542.6
Purity	≥98%
Solubility	Soluble in ethyl acetate (10mg/ml) or DMSO.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Crosstalk between pro-survival sphingolipid metabolism and complement signaling induces inflammasome-mediated tumor metastasis: Janneh, A. H., Kassir, M. F., et al.; Cell Rep. 41, 111742 (2022), Abstract
Identification of host factors involved in borna disease virus cell entry through a small interfering RNA functional genetic screen: R. Clemente, et al.; J. Virol. 84, 3562 (2010), Abstract — Full Text
Loss of cathepsin L activity promotes claudin-1 overexpression and intestinal neoplasia: F. Boudreau, et al.; FASEB J. 21, 3853 (2007), Abstract — Full Text
Analysis of filovirus entry into vero e6 cells, using inhibitors of endocytosis, endosomal acidification, structural integrity, and cathepsin (B and L) activity: A. Sanchez; J. Infect. Dis. 196, S251 (2007), Abstract — Full Text
The affinity-labelling of cathepsin S with peptidyl diazomethyl ketones. Comparison with the inhibition of cathepsin L and calpain: E. Shaw, et al.; FEBS Lett. 334, 340 (1993), Abstract