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SNAP

BML-CN210

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Releases NO under physiological conditions

Stable analog of endogenous S-nitroso compounds. Nitric oxide (NO) donor and a source of NO in vivo which spontaneously releases NO under physiological conditions. The half-life time is 4.6 hours in aqueous media. Potent vasodilator in vitro and in vivo that does not induce pharmacological tolerance. Relaxes isolated bovine coronary artery rings with an EC50=0.1µM. It also inhibits vascular smooth muscle cell mitogenesis and proliferation, inhibits leukocyte adherence to endothelium, and inhibits cysteine proteases. The unique NO releasing properties of SNAP make it an ideal agent for studying the pharmacological and physiological actions of NO.

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Product Details

Alternative Name	S-Nitroso-N-acetyl-D,L-penicillamine
Appearance	Green crystalline solid.
CAS	79032-48-7
Couple Target	Protease
Couple Type	Inhibitor
Formula	C₇H₁₂N₂O₄S
MW	220.3
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (25mg/ml) 100% ethanol (25mg/ml) or methanol; slightly soluble in water (2mg/ml).
Source	Synthetic.
Technical Info / Product Notes	Note: Product is not sterile.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for up to 1 year after receipt when stored at -20°C.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Connexin 43 Affects Pulmonary Artery Reactivity via Changes in Nitric Oxide Production and Influences Proliferative and Migratory Responses in Mouse Pulmonary Artery Fibroblasts: Wali, S. M., Hwej, A., et al.; Int. J. Mol. Sci. 26, (2025), Abstract
Dysregulated Expression of Arginine Metabolic Enzymes in Human Intestinal Tissues of Necrotizing Enterocolitis and Response of CaCO2 Cells to Bacterial Components: K.T. Leung, et al.; J. Nutr. Biochem. 29, 64 (2016), Application(s): NO supplementation in CaCO2 cells, Abstract
Molecular Magnetic Resonance Imaging of Angiogenesis In Vivo using Polyvalent Cyclic RGD-Iron Oxide Microparticle Conjugates: S. Melemenidis, et al.; Theranostics 5, 515 (2015), Application(s): Cell Culture, Abstract — Full Text
Circadian phase-dependent effect of nitric oxide on L-type voltage-gated calcium channels in avian cone photoreceptors: Ko, M. L., Shi, L., et al.; J. Neurochem. 127, 314 (2013), Abstract
Expression and subcellular localization of BNIP3 in hypoxic hepatocytes and liver stress: Metukuri, M. R., Beer-Stolz, D., et al.; Am. J. Physiol. Gastrointest. Liver Physiol. 296, G499 (2009), Abstract
Perinatal hypoxia triggers alterations in K+ channels of adult pulmonary artery smooth muscle cells: Marino, M., Bény, J. L., et al.; Am. J. Physiol. Lung Cell. Mol. Physiol. 293, L1171 (2007), Abstract
SNAP, a NO donor, induces cellular protection only when cortical neurons are submitted to some aggression process: S. Figueroa, et al.; Brain Res. 1034, 25 (2005), Abstract
The reaction of S-nitroso-N-acetyl-D,L-penicillamine (SNAP) with the angiotensin converting enzyme inhibitor, captopril–mechanism of transnitrosation: D.V. Aquart & T.P. Dasgupta; Org. Biomol. Chem. 3, 1640 (2005), Abstract
SNAP, a NO donor, induces cortical neuron death by a mechanism in which the caspase pathway is implicated: S. Figueroa, et al.; Brain Res. 1047, 168 (2005), Abstract
In vitro cytotoxicity of glyco-S-nitrosothiols. a novel class of nitric oxide donors: H. Babich & H.L. Zuckerbraun; Toxicol. In Vitro 15, 181 (2001), Abstract

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Last modified: May 29, 2024

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SNAP

BML-CN210

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