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SIRT2 (human), (recombinant) (His-tag)

BML-SE251

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Due to their roles in gene silencing, aging, and oxidative stress responses, it is believed that sirtuins (NAD-dependent lysine deacetylases) play a crucial role in cell metabolism. Human SIRT2 is a class I sirtuin, although not as closely related to Sir2 and human SIRT1. Its catalytic core has the same basic two-domain architecture and central groove as other sirtuins and an interaction with the homeobox transcription factor HOXA10.

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Product Details

Alternative Name	Sirtuin 2
Formulation	Liquid. In 25mM TRIS, pH 7.5, containing 100mM NaCl, 5mM DTT and 10% glycerol.
MW	43 kDa
Purity Detail	Purified by multi-step chromatography.
Source	Produced in E. coli. Contains a N-terminal His-tag.
Specific Activity	One unit will deacetylate 1pmol/min of FLUOR DE LYS^®-SIRT2 substrate (Prod. No. BML-KI179).
UniProt ID	Q8IXJ6

Handling & Storage

Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Pharmacophore modeling and virtual screening studies to identify novel selective SIRT2 inhibitors: G. Eren, et al.; J. Mol. Graph. Model. 10, 1313 (2019), Abstract
Discovery of bicyclic pyrazoles as class III histone deacetylase SIRT1 and SIRT2 inhibitors: E. Therrien, et al.; Bioorg. Med. Chem. Lett. 25, 2514 (2015), Abstract
Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase: V. Nin, et al.; J. Biol. Chem. 287, 23489 (2012), Abstract — Full Text
A mechanism-based potent sirtuin inhibitor containing Nε-thiocarbamoyl-lysine (TuAcK): B.M. Hirsch, et al.; Bioorg. Med. Chem. Lett. 21, 4753 (2011), Abstract — Full Text
Identification of Diketopiperazine-Containing 2-Anilinobenzamides as Potent Sirtuin 2 (SIRT2)-Selective Inhibitors Targeting the Selectivity Pocket”: Substrate-Binding Site; and NAD+-Binding Site””” P. Mellini, et al., J. Med. Chem. (62), 5844, Abstract

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SIRT2 (human), (recombinant) (His-tag)

BML-SE251

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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