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SIRT1 (human), (recombinant) (His-tag)

BML-SE239

17 citations

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Product Details

Alternative Name	Sirtuin 1
Formulation	Liquid. In 25 mM TRIS, pH 7.5, 100mM NaCl, 5mM DTT and 10% glycerol.
Gene/Protein Identifier	NM_012238 (RefSeq)
MW	82 kDa
Purity Detail	Partially purified by single-step affinity chromatography and gel filtration.
Source	Produced in E. coli. Recombinant SIRT1 from human cDNA containing an N-terminal His-tag.
Specific Activity	One unit = 1pmol/min at 37°C, 250µM FLUOR DE LYS^® substrate (Prod. No. BML-KI104), 500µM NAD⁺.
UniProt ID	Q96EB6

Handling & Storage

Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Acetylation-induced proteasomal degradation of the activated glucocorticoid receptor limits hormonal signaling: Iyer-Bierhoff, A., Wieczorek, M., et al.; iScience 27, 108943 (2024), Abstract
Interaction between RECQL4 and OGG1 promotes repair of oxidative base lesion 8-oxoG and is regulated by SIRT1 deacetylase: Duan, S., Han, X., et al.; Nucleic Acids Res. 48, 6530 (2020), Application(s): WB, Abstract
Pharmacophore modeling and virtual screening studies to identify novel selective SIRT2 inhibitors: G. Eren, et al.; J. Mol. Graph. Model. 10, 1313 (2019), Abstract
Two Novel Proline-Containing Catechin Glucoside from Water-Soluble Extract of Codonopsis pilosula: F.Y. Qin, et al.; Molecules 23, E180 (2018), Application(s):SIRT1 Inhibition, Abstract — Full Text
Discovery of bicyclic pyrazoles as class III histone deacetylase SIRT1 and SIRT2 inhibitors: E. Therrien, et al.; Bioorg. Med. Chem. Lett. 25, 2514 (2015), Abstract
Functionalized tetrahydro-1H-pyrido[4,3-b]indoles: a novel chemotype with Sirtuin 2 inhibitory activity: T. Yang, et al.; Eur. J. Med. Chem. 92, 145 (2015), Abstract
Design, synthesis and structure-activity relationship studies of novel sirtuin 2 (SIRT2) inhibitors with a benzamide skeleton: T. Sakai, et al.; Bioorg. Med. Chem. 23, 328 (2015), Abstract
AROS has a context-dependent effect on SIRT1: T. Kokkola, et al.; FEBS Lett. 588, 1523 (2014), Application(s): In vitro activity assay, Abstract
Redox Factor-1 Activates Endothelial SIRTUIN1 through Reduction of Conserved Cysteine Sulfhydryls in Its Deacetylase Domain: S.B. Jung, et al.; PLoS One 8, e65415 (2013), Abstract — Full Text
Cytotoxicity and cell death mechanisms induced by a novel bisnaphthalimidopropyl derivative against the NCI-H460 non-small lung cancer cell line: R.T. Lima, et al.; Anticancer Agents Med. Chem. 13, 414 (2013), Abstract

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SIRT1 (human), (recombinant) (His-tag)

BML-SE239

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SIRT1 (human), (recombinant) (His-tag)

BML-SE239

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FLUOR DE LYS® deacetylase substrate

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FLUOR DE LYS^® deacetylase substrate