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Pertussis toxin (Bordetella pertussis)

BML-G100

35 citations

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Manual
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Ultra-pure pertussis toxin delivering optimal antigenicity

Higher specificity and sensitivity
Minimal lot-to-lot variation
Reproducible scale-up for bulk quantities
Lyophilized format for extended shelf-life

Pertussis toxin consists of an enzymatically active A protomer subunit (S-1) which possesses both NAD⁺ glycohydrolase and ADP-ribosyltransferase activities and a B oligomer subunit (S-2, S-3, S-4, and S-5) which is responsible for attachment of the native toxin to eukaryotic cell surfaces. Pertussis toxin uncouples G proteins from receptors by ADP ribosylating a cysteine near the carboxy-terminus of the A subunit.

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Product Details

Alternative Name	Islet-activating protein, PTX, Holotoxin
CAS	70323-44-3
Formulation	Lyophilized. Containing sodium phosphate and sodium chloride.
Purity	≥95%
Purity Detail	Purified by SDS-PAGE.
Source	From Bordetella pertussis, strain 165.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. This preparation is lyophilized, aseptically packaged and sealed under vacuum. Do not vortex. Store at 4°C prior to and following reconstitution. Do not freeze. Activation Status: Please note that this product is supplied in a non-activated state. If your system requires activation, refer to Kaslow et al. (1987) Biochemistry 26, 123-127. Each vial when reconstituted to 500 μL with sterile distilled water, contains 50.0 μg of pertussis toxin in 10 mM sodium phosphate buffer with 50 mM sodium chloride at pH 7.0. The toxin is not completely soluble and the resulting suspension should be made uniform by gentle mixing, not vortexing, prior to withdrawing aliquots. Do not sterile filter. This product should be used only by technically qualified personnel. Good laboratory technique must be employed. This product should be used only by technically qualified personnel. Refer to the Safety Data Sheet (SDS) for complete handling, safety, and first aid information.
Handling	Aseptically packed, sealed under vacuum. Do not vortex. Do not freeze.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Grape Seed Extract Attenuates Demyelination in Experimental Autoimmune Encephalomyelitis Mice by Inhibiting Inflammatory Response of Immune Cells: Q. Wang, et al.; Chin. J. Integr. Med. , (2023), Abstract
Remyelination in neuromyelitis optica spectrum disorder is promoted by edaravone through mTORC1 signaling activation: W. Luo, et al.; Glia 71, 284 (2023), Abstract
Ferroptosis induces detrimental effects in chronic EAE and its implications for progressive MS: P. Jhelum, et al.; Acta Neuropathol. Commun. 11, 121 (2023), Abstract
Hematopoietic stem and progenitor cells integrate microbial signals to promote post-inflammation gut tissue repair: Sezaki, M., Hayashi, Y., et al.; EMBO J. 41, e110712 (2022), Abstract
Cladribine treatment improves cortical network functionality in a mouse model of autoimmune encephalomyelitis: C.B. Schroeter, et al.; J. Neuroinflammation 19, 270 (2022), Abstract
CAL-1 as Cellular Model System to Study CCR7-Guided Human Dendritic Cell Migration: E.U. Allmen, et al.; Front. Immunol. 12, 702453 (2021), Abstract
Hematopoietic stem and progenitor cells integrate i>Bacteroides/i>-derived innate immune signals to promote gut tissue repair: Hayashi, Y., Sezaki, M., et al.; bioRxiv , (2021)
Cytotoxic effect of specific T cells from mice with experimental autoimmune uveitis on murine photoreceptor cells: Z. Liu, et al.; Int. J. Ophthalmol. 13, 1180 (2020), Abstract — Full Text
Oleanolic Acid Acetate Alleviates Symptoms of Experimental Autoimmune Encephalomyelitis in Mice by Regulating Toll-Like Receptor 2 Signaling: Kim, M., Lee, S., et al.; Front. Pharmacol. 11, 556391 (2020), Abstract
Penicillin causes non-allergic anaphylaxis by activating the contact system: Y. Gao, et al.; Sci. Rep. 10, 14183 (2020), Abstract — Full Text

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Available

Bordetella pertussis toxin

BML-G101

High purity toxin with minimal lot-to-lot variation

12 citations

Alternative Name	Islet-activating protein, PTX
Purity	≥98%
Source	From Bordetella pertussis, strain NCTC 10739.

Last modified: May 29, 2024

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Pertussis toxin (Bordetella pertussis)

BML-G100

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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