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Nicotinamide

BML-KI283

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Nicotinamide, the water-soluble amide of nicotinic acid, is a component of the two most important coenzymes – nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate. Thus nicotinamide is involved in numerous oxidation-reduction reactions in mammalian biological systems acting as an antioxidant.

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Product Details

Appearance	Clear solution.
CAS	98-92-0
Formula	C₆H₆N₂O
Formulation	50 mM Nicotinamide in 50 mM Tris/Cl, pH 8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl₂.
MI	14: 6523
MW	122.1
Solubility	Soluble in water, 100% ethanol or glycerol. Slightly soluble in chloroform, almost insoluble in ether or acetone.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at -70°C for up to 1 year.
Long Term Storage	-80°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

An optimized desuccinylase activity assay reveals a difference in desuccinylation activity between proliferative and differentiated cells: Yuan, T., Keijer, J., et al.; Sci. Rep. 10, 17030 (2020), Abstract
Two Novel Proline-Containing Catechin Glucoside from Water-Soluble Extract of Codonopsis pilosula: F.Y. Qin, et al.; Molecules 23, E180 (2018), Application(s):SIRT1 Inhibition, Abstract — Full Text
Histone deacetylase (HDAC) 1 controls the expression of beta defensin 1 in human lung epithelial cells: K. Kallsen, et al.; PLoS One 7, e50000 (2012), Application(s): In Vitro, Abstract — Full Text
Identification of Diketopiperazine-Containing 2-Anilinobenzamides as Potent Sirtuin 2 (SIRT2)-Selective Inhibitors Targeting the Selectivity Pocket”: Substrate-Binding Site; and NAD+-Binding Site””” P. Mellini, et al., J. Med. Chem. (62), 5844, Abstract

Last modified: May 29, 2024

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Nicotinamide

BML-KI283

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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