N-Oleylethanolamide

BML-SL231

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TRPV1 activator

Activates TRPV1. Endogenous anandamide-like lipid which regulates appetite but does not bind to cannabinoid receptors. In rats, food intake is inhibited by oral oleylethanolamide. Induces satiety by activation of PPARα. Inhibits ceramidase.

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Product Details

Appearance	White solid.
CAS	111-58-0
Couple Target	Ceramidase, PPAR, TRP channel
Couple Type	Activator, Inhibitor, Ligand
Formula	C₂₀H₃₉NO₂
MW	325.5
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (>25mg/ml), methanol or 100% ethanol (>25mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR-alpha): M. Guzman, et al.; J. Biol. Chem. 279, 27849 (2004), Abstract
Food intake is inhibited by oral oleoylethanolamide: M.J. Nielsen, et al.; J. Lipid Res. 45, 1027 (2004), Abstract
Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha: J. Fu, et al.; Nature 425, 90 (2003), Abstract
Activation of TRPV1 by the satiety factor oleoylethanolamide: G.P. Ahern; J. Biol. Chem. 278, 30429 (2003), Abstract
A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding: R. Gomez, et al.; J. Neurosci. 22, 9612 (2002), Abstract
An anorexic lipid mediator regulated by feeding: F. Rodriguez de Fonseca, et al.; Nature 414, 209 (2001), Abstract
Anti-immunoglobulin-induced apoptosis in WEHI 231 cells involves the slow formation of ceramide from sphingomyelin and is blocked by bcl-XL: D.A. Wiesner, et al.; J. Biol. Chem. 272, 9868 (1997), Abstract
Cannabinomimetic behavioral effects of and adenylate cyclase inhibition by two new endogenous anandamides: J. Barg, et al.; Eur. J. Pharmacol. 287, 145 (1995), Abstract
Differential regulation of sphingomyelinase and ceramidase activities by growth factors and cytokines. Implications for cellular proliferation and differentiation: E. Coroneos, et al.; J. Biol. Chem. 270, 23305 (1995), Abstract
Two new unsaturated fatty acid ethanolamides in brain that bind to the cannabinoid receptor:: L. Hanus, et al.; J. Med. Chem. 36, 3032 (1993), Abstract

Last modified: May 29, 2024

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N-Oleylethanolamide

BML-SL231

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