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Methotrexate

ALX-440-045

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Dihydrofolate reductase inhibitor

Folic acid antagonist. Potent inhibitor of dihydrofolate reductase. Induces apoptosis. Inhibits DNA synthesis. Anticancer agent.

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Product Details

Alternative Name	(+)-Amethopterin, 4-Amino-10-methylfolic acid, Methylaminopterin, MTX
Appearance	Yellow powder.
CAS	133073-73-1
Couple Target	Dihydrofolate reductase
Couple Type	Inhibitor
Formula	C₂₀H₂₂N₈O₅ . H₂O
MI	14: 5985
MW	454.5
Purity	≥98% (HPLC)
Solubility	Soluble in alkaline solution; insoluble in water, 100% ethanol or ether.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

High-Throughput Phenotypic Screening and Machine Learning Methods Enabled the Selection of Broad-Spectrum Low-Toxicity Antitrypanosomatidic Agents: Linciano, P., Quotadamo, A., et al.; J. Med. Chem. 66, 15230 (2023), Abstract
The VINE complex is an endosomal VPS9-domain GEF and SNX-BAR coat: Shortill, S. P., Frier, M. S., et al.; Elife 11, (2022), Abstract
Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform: Moraes, C. B., Witt, G., et al.; SLAS Discov. 24, 346 (2019), Abstract
Antiproliferative and antiinflammatory effects of methotrexate on cultured differentiating myeloid monocytic cells (THP-1) but not on synovial macrophages from patients with rheumatoid arthritis: M. Cutolo, et al.; J. Rheumatol. 27, 2551 (2000), Abstract
Mechanisms of action of methotrexate: L. Genestier, et al.; Immunopharmacology 47, 247 (2000), Abstract
Methotrexate inhibits the first committed step of purine biosynthesis in mitogen-stimulated human T-lymphocytes: a metabolic basis for efficacy in rheumatoid arthritis?: L.D. Fairbanks, et al.; Biochem. J. 342, 143 (1999), Abstract
Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T cells: L. Genestier, et al.; J. Clin. Invest. 102, 322 (1998), Abstract
Methotrexate induces apoptotic cell death in human keratinocytes: M. Heenen, et al.; Arch. Dermatol. Res. 290, 240 (1998), Abstract
Activation-dependent lymphocyte apoptosis induced by methotrexate: R. Paillot, et al.; Transplant. Proc. 30, 2348 (1998), Abstract
Characteristics of cancer cell death after exposure to cytotoxic drugs in vitro: L.I. Huschtscha, et al.; Br. J. Cancer. 73, 54 (1996), Abstract

Last modified: May 29, 2024

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Methotrexate

ALX-440-045

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