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Cyclopiazonic acid

BML-CA415

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ATPase inhibitor

Mycotoxin. Cell permeable. Induces the release of intracellular stored Ca²⁺ without increasing IP3 levels via inhibition of endoplasmic reticulum Ca²⁺-ATPase. Highly specific inhibitor of Ca²⁺-ATPase of sarcoplasmic reticulum, completely inhibiting the enzyme at 6-8 nmol/mg protein (at 0.5-2.0µM ATP).

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Product Details

Alternative Name	CPA
Appearance	Off-white to faint yellow solid.
CAS	18172-33-3
Couple Target	ATPase
Couple Type	Inhibitor
Formula	C₂₀H₂₀N₂O₃
MW	336.4
Purity	≥98% (TLC)
RTECS	UY8587000
Solubility	Soluble in DMSO (20mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Vanillin Induces Relaxation in Rat Mesenteric Resistance Arteries by Inhibiting Extracellular Ca2+ Influx: S. Choi, et al.; Molecules 28, 288 (2023), Abstract
Extracellular and ER-stored Ca2+ contribute to BIRD-2-induced cell death in diffuse large B-cell lymphoma cells: Bittremieux, M., La Rovere, R. M., et al.; Cell Death Discov. 4, 101 (2018), Abstract
DPB162-AE, an inhibitor of store-operated Ca2+ entry, can deplete the endoplasmic reticulum Ca2+ store: M. Bittremieux, et al.; Cell Calcium 62, 60 (2017), Application(s): Treatment of pancreatic acinar cells, Abstract
Mechanisms of tau and Aβ-induced excitotoxicity: Pallo, S. P., DiMaio, J., et al.; Brain Res. 1634, 119 (2016), Abstract
Stromal Interaction Molecule 1 Rescues Store-Operated Calcium Entry and Protects NG115-401L Cells Against Cell Death Induced by Endoplasmic Reticulum and Mitochondrial Oxidative Stress: C. Zhang, et al.; Neurochem. Int. 97, 137 (2016), Application(s): Cell culture, Abstract
Ca(2+) is a Regulator of the WNK/OSR1/NKCC Pathway in a Human Salivary Gland Cell Line: S. Park, et al.; Korean J. Physiol. Pharmacol. 19, 249 (2015), Application(s): Cell Culture, Abstract — Full Text
Role of ion channels and subcellular Ca2+ signaling in arachidonic acid-induced dilation of pressurized retinal arterioles: Kur, J., McGahon, M. K., et al.; Invest. Ophthalmol. Vis. Sci. 55, 2893 (2014), Abstract
Ca2+ oscillations, Ca2+ sensitization, and contraction activated by protein kinase C in small airway smooth muscle: Mukherjee, S., Trice, J., et al.; J. Gen. Physiol. 141, 165 (2013), Abstract
Cyclopiazonic acid reduces the coupling factor of the Ca2+-ATPase acting on Ca2+ binding: F. Martinez-Azorin; FEBS Lett. 576, 73 (2004), Abstract
Recent advances in analytical methodology for cyclopiazonic acid: J.W. Dorner; Adv. Exp. Med. Biol. 504, 107 (2002), Review, Abstract

Last modified: May 29, 2024

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Cyclopiazonic acid

BML-CA415

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