Inquire for Availability

Clozapine

BML-D107

Datasheet
Manual
SDS
CofA

Already have an account?

Dopamine receptor and serotonin receptor antagonist

Dopamine D₄ and D₂ receptor antagonist. High affinity for the cloned rat dopamine D4 receptor (K_i<20nM). Atypical neuroleptic agent. Antagonist at 5HT_2A, 5HT_2C, 5HT₃, 5HT₆ and 5HT₇ receptors.

Shipping: Available products typically ship within 24/48h, via priority shipping.

Do you need support? Contact Customer Service or Technical Support.

Online Account
Access or Create Your Account

Product Details

Alternative Name	8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e]-[1,4]diazepine
Appearance	Yellow crystalline powder.
CAS	5786-21-0
Couple Target	Dopamine receptor, Serotonin receptor
Couple Type	Ligand
Formula	C₁₈H₁₉ClN₄
Identity	Determined by IR.
MI	14: 2423
MW	326.8
Purity	≥99% (HPLC)
RTECS	HP1750000
Solubility	Soluble in DMSO (30mg/ml) or dilute aqueous acid.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways: J. Midkiff, et al.; PLoS One 6, e25395 (2011), Abstract — Full Text
Interaction of clozapine with the histamine H3 receptor in rat brain: A.A. Rodrigues, et al.; Br. J. Pharmacol. 114, 1523 (1995), Abstract
D4 dopamine receptor binding affinity does not distinguish between typical and atypical antipsychotic drugs: B.L. Roth, et al.; Psychopharmacology 120, 365 (1995), Abstract
Role of serotonin in the action of atypical antipsychotic drugs: H.Y. Meltzer; Clin. Neurosci. 3, 64 (1995), Abstract
5-HT1C receptor-mediated phosphoinositide hydrolysis in the rat choroid plexus after chronic treatment with clozapine: M. Kuoppamaki, et al.; Eur. J. Pharmacol. 255, 91 (1994), Abstract
Clozapine is a potent and selective muscarinic M4 receptor agonist: S.H. Zorn, et al.; Eur. J. Pharmacol. 269, R1 (1994), Abstract
Clozapine and N-desmethylclozapine are potent 5-HT1C receptor antagonists: M. Kuoppamaki, et al.; Eur. J. Pharmacol. 245, 179 (1993), Abstract
The involvement of dopamine D1 and D2 receptors in the effects of the classical neuroleptic haloperidol and the atypical neuroleptic clozapine: B.A. Ellenbroek, et al.; Eur. J. Pharmacol. 196, 103 (1991), Abstract
Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine: H.H. Van Tol, et al.; Nature 350, 610 (1991), Abstract
Binding of typical and atypical antipsychotics to 5-HT1C and 5-HT2 sites: clozapine potently interacts with 5-HT1C sites: H. Canton, et al.; Eur. J. Pharmacol. 191, 93 (1990), Abstract

Related Products

Inquire for Availability

(+)-Bicuculline

ALX-550-515

GABA_A receptor antagonist

7 citations

Alternative Name	D-Bicuculline
CAS	485-49-4
Couple Type	Inhibitor, Ligand
Purity	≥98% (HPLC)

Inquire for Availability

(+)-Egenine

ALX-350-362

6 citations

Alternative Name	6-(6-Methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-6,8-dihydrofuro[3,4-E][1,3]benzodioxol-8-ol, (+)-Decumbensine
CAS	6883-44-9
Purity	≥98% (HPLC)

Available

(+)-Himbacine

ALX-550-061

Muscarinic acetylcholine receptor antagonist

8 citations

Alternative Name	(3S,3aR,4R,4aS,8aR,9aS)-4-[(1E)-2-[(2R,6S)-1,6-Dimethyl-2-piperdinyl]ethenyl]decahydro-3-methyl-naphtho[2,3-c]furan-1(3H)-one
CAS	6879-74-9
Couple Type	Inhibitor
Purity	≥98%

Available

(+)-Indolactam V

ALX-420-010

CAS	90365-56-3
Purity	≥95% (1H-NMR)

Last modified: May 29, 2024

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Datasheet

Certificate of Analysis

Please enter the lot number as featured on the product label

Lot No. :

SDS

Enzo Life Science provides GHS Compliant SDS

English (EU) SDS

If your language is not available please fill out the SDS request form

Your Cart

Your Cart

Clozapine

BML-D107

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

Change Country

Tell us about You

Tell us about your paper

Tell us about You

Tell us about your project