γ-Glutamyl transpeptidase inhibitor
L-Buthionine-sulfoximine (BSO) induces oxidative stress in cells by irreversibly inhibiting γ-glutamylcysteine synthetase, an essential enzyme for the synthesis of glutathione.
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Product Details
| Alternative Name |
BSO |
|---|---|
| Appearance |
White solid. |
| CAS |
83730-53-4 |
| Couple Target |
gamma-Glutamyl transpeptidase |
| Couple Type |
Inhibitor |
| Formula |
C8H18N2O3S |
| MW |
222.3 |
| Purity |
≥97% (TLC) |
| Solubility |
Soluble in water. |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. |
|---|---|
| Long Term Storage |
-20°C |
| Shipping |
Ambient Temperature |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Mapping glutathione utilization in the developing zebrafish (Danio rerio) embryo: Rastogi, A., Clark, C. W., et al.; Redox Biol. 26, 101235 (2019), Abstract
- A bacterial metabolite induces glutathione-tractable proteostatic damage, proteasomal disturbances, and PINK1-dependent autophagy in C. elegans: B.A. Martinez, et al.; Cell Death Dis. 6, e1908 (2015), Application(s): Cell Culture, Abstract — Full Text
- Manganese superoxide dismutase knock-down in 3T3-L1 preadipocytes impairs subsequent adipogenesis: S. Krautbauer, et al.; Mol. Cell. Biochem. 393, 69 (2014), Application(s): Treatment of 3T3-L1 cells in culture, Abstract
- Glutathione depletion by buthionine sulfoximine induces DNA deletions in mice: R. H. Schiestl & R. Reliene; Carcinogenesis 27, 240 (2006), Abstract
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|---|---|
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|---|---|
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Last modified: May 29, 2024
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