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AEBSF . hydrochloride

ALX-270-022

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Serine protease inhibitor

Specific irreversible inhibitor of serine proteases including trypsin, chymotrypsin, plasmin, plasma kallikrein, and thrombin. Stable, non-toxic alternative to PMSF (Prod. No. ALX-270-184). Inhibitor of NAD(P)H oxidase. Activator of MAP kinases JNK and p38.

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Product Details

Alternative Name	4-(2-Aminoethyl)benzenesulfonylfluoride . HCl, Pefabloc®SC
Appearance	White to off-white powder.
CAS	30827-99-7
Couple Target	Jnk, NADPH oxidase, p38, Serine protease
Couple Type	Activator, Inhibitor
Formula	C₈H₁₀FNO₂S . HCl
MW	239.7
Purity	≥98% (HPLC)
Solubility	Soluble in water or 100% ethanol.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from moisture and light.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

UBQLN2 undergoes a reversible temperature-induced conformational switch that regulates binding with HSPA1B: ALS/FTD mutations cripple the switch but do not destroy HSPA1B binding: T.H. Phung, et al.; Biochim. Biophys. Acta Gen. Subj. 1867, 130284 (2023), Abstract
Bifunctional hetero di-disc for broad-spectrum influenza neutralization: S. Moon, et al.; Nanomedicine 44, 102587 (2022), Abstract
Virucidal nano-perforator of viral membrane trapping viral RNAs in the endosome: Kong, B., Moon, S., et al.; Nat. Commun. 10, 185 (2019), Abstract
TANK-binding kinase 1 (TBK1) modulates inflammatory hyperalgesia by regulating MAP kinases and NF-κB dependent genes: C. V. Möser, et al.; J. Neuroinflammation 12, 100 (2015), Application(s): Western Blot, Abstract — Full Text
AMP-activated protein kinase Is activated by non-steroidal anti-inflammatory drugs: T.S. King, et al.; Eur. J. Pharmacol. 762, 299 (2015), Application(s): Western Blot, Abstract
Inhibitory effect of 4-(2-aminoethyl)-benzenesulfonyl fluoride, a serine protease inhibitor, on PI3K inhibitor-induced CHOP expression: T. Hosoi, et al.; Eur. J. Pharmacol. 554, 8 (2007), Abstract
Heme oxygenase-1 gene activation by the NAD(P)H oxidase inhibitor 4-(2-aminoethyl) benzenesulfonyl fluoride via a protein kinase B, p38-dependent signaling pathway in monocytes: N. Wijayanti, et al.; J. Biol. Chem. 280, 21820 (2005), Abstract — Full Text
Evaluation of two inhibitors of invasion: LY311727 [3-(3-acetamide-1-benzyl-2-ethyl-indolyl-5-oxy)propane phosphonic acid] and AEBSF [4-(2-aminoethyl)-benzenesulphonyl fluoride] in acute murine toxoplasmosis: R. Buitrago-Rey, et al.; J. Antimicrob. Chemother. 49, 871 (2002), Abstract — Full Text
4-(2-Aminoethyl)benzenesulfonyl fluoride attenuates tumor-necrosis-factor-alpha-induced blood-brain barrier opening: P. Megyeri, et al.; Eur. J. Pharmacol. 374, 207 (1999), Abstract
Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds: V. Diatchuk, et al.; J. Biol. Chem. 272, 13292 (1997), Abstract — Full Text

Related Products

Phenylmethylsulfonyl fluoride

ALX-270-184

Inhibitor of serine proteases and FAAH

13 citations

Alternative Name	PMSF, Benzylsulfonyl fluoride
CAS	329-98-6
Couple Type	Inhibitor
Purity	≥99% (HPLC)

Last modified: May 29, 2024

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AEBSF . hydrochloride

ALX-270-022

Product Details

Handling & Storage

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