5-Iodotubercidin

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Protein kinase inhibitor

Inhibits ERK2 (Ki = 525nM). Also inhibits adenosine kinase (Ki = 30nM), CK1 and CK2 and insulin receptor kinase (IC50 ranging from 0.4-28µM).

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Alternative Name	4-Amino-5-iodo-7-(β-D-ribofuranosyl)-pyrrolo[2,3-d]pyrimidine
Appearance	Off-white solid
CAS	24386-93-4
Couple Target	Adenosine kinase, Casein kinase, Erk, Insulin receptor
Couple Type	Inhibitor
Formula	C₁₁H₁₃IN0₄
Identity	Determined by 1H-NMR and MS
MW	392.1
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (25mg/ml) or 100% ethanol (8mg/ml warm)

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase: T. Fox et al.; Protein. Sci. 7, 2249 (1998), Abstract
Identification of the glycogenic compound 5-iodotubercidin as a general protein kinase inhibitor: D. Massillon et al.; Biochem. J. 299, 123 (1994), Abstract

Last modified: May 29, 2024

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