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1400W . dihydrochloride

ALX-270-073

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iNOS inhibitor

A slow, tight binding and highly selective inhibitor of inducible nitric oxide synthase (iNOS/NOS II) in vitro and in vivo. Binds tightly to iNOS with a K_d of 7nM. In contrast, inhibition of nNOS and eNOS is weaker and rapidly reversible with K_i values of 2 and 50µM respectively. Inhibits tumor growth in vivo. Prevents circulatory failure but not organ injury induced by endotoxin. Displays protective effects in oxygen-deprived brain slices.

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Product Details

Appearance	White to off-white powder.
CAS	214358-33-5
Couple Target	NOS
Couple Type	Inhibitor
Formula	C₁₀H₁₅N₃ . 2HCl
Identity	Determined by NMR.
MW	250.17
Purity	≥95% (TLC)
Solubility	Soluble in water (up to 25mg/ml), methanol or DMSO.
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Hygroscopic.
Short Term Storage	-20°C
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Differential Effects of D9 Tetrahydrocannabinol (THC)- and Cannabidiol (CBD)-Based Cannabinoid Treatments on Macrophage Immune Function In Vitro and on Gastrointestinal Inflammation in a Murine Model: Z. Yekhtin, et al.; Biomedicines 10, 1793 (2022), Abstract
The metabolic adaptation evoked by arginine enhances the effect of radiation in brain metastases: R. Marullo, et al.; Sci. Adv. 7, eabg1964 (2021), Abstract
Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes: Karki, R., Sharma, B. R., et al.; Cell 184, 149 (2021), Application(s): In Vitro, Abstract
A high-performance genetically encoded fluorescent biosensor for imaging physiological peroxynitrite: Chen, Z., Zhang, S., et al.; Cell Chem. Biol. 28, 1542 (2021), Abstract
Inflammatory Cell Death, PANoptosis, Mediated by Cytokines in Diverse Cancer Lineages Inhibits Tumor Growth: R.K.S. Malireddi, et al.; Immunohorizons 5, 568 (2021), Abstract
GPR30 Attenuates Myocardial Fibrosis in Diabetic Ovariectomized Female Rats: Role of iNOS Signaling: X. Wang, et al.; DNA Cell Biol. 37, 821 (2018), Abstract
Chemically Bonding of Amantadine with Gardenamide A Enhances the Neuroprotective Effects against Corticosterone-Induced Insults in PC12 Cells: J. Zhao, et al.; Int. J. Mol. Sci. 16, 22795 (2015), Application(s): Cell Culture, Abstract — Full Text
Pretreatment with Relaxin Does Not Restore NO-Mediated Modulation of Calcium Signal in Coronary Endothelial Cells Isolated from Spontaneously Hypertensive Rats: S. Nistri, et al.; Molecules 20, 9524 (2015), Application(s): Cell Culture, Abstract — Full Text
Levosimendan inhibits interleukin-1β-induced apoptosis through activation of Akt and inhibition of inducible nitric oxide synthase in rat cardiac fibroblasts: M. Okada, et al.; Eur. J. Pharmacol. 769, 86 (2015), Application(s): Cell culture , Abstract
Toll-like receptor 4 signaling confers cardiac protection against ischemic injury via inducible nitric oxide synthase- and soluble guanylate cyclase-dependent mechanisms: E. Wang, et al.; Anesthesiology 114, 603 (2010), Abstract — Full Text

Last modified: May 29, 2024

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1400W . dihydrochloride

ALX-270-073

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Handling & Storage

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