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Small Molecule Chemistry
Does PACOCF3, BML-ST336 inhibit all isoforms of phospholipase A2 (PLA2)?
PACOCF3 (BML-ST336) inhibits of both Ca2+-dependent cytosolic cPLA2 (IC50=45 µM) and Ca2+-independent phospholipases A2 iPLA2 (IC50=3.8 µM). Unfortunately, we have…
Tue, Jul 18, 2023
Why your SCREEN-WELL® Natural product library (BML-2865) supplied in mg/mL instead of mM?
When our SCREEN-WELL® Natural product library (BML-2865) library was originally developed, we included some very exotic compounds. Unlike synthetic chemicals,…
Tue, Jul 18, 2023
How many compounds in your SCREEN-WELL® Kinase inhibitor library (BML-2832) are FDA-approved?
We have cross-listed the compounds included in our SCREEN-WELL® kinase inhibitor library (BML-2832) with the compounds included in our SCREEN-WELL®…
Tue, Jul 18, 2023
How many compounds in your SCREEN-WELL® Neurotransmitter library (BML-2810) are clinically approved?
We did an overlap analysis of our SCREEN-WELL® Neurotransmitter library (BML-2810) with our SCREEN-WELL® FDA-approved drug library (BML-2843) and there…
Tue, Jul 18, 2023
Which software can I use to open the SD files that come with the SCREEN-WELL® compound libraries?
Structure files (or SD files) can be opened using the ISIS/BASE software. ISIS/BASE is the only program that can read…
Tue, Jul 18, 2023
How should I dilute my SCREEN-WELL® compound library for my assay?
Each one of the compounds are supplied at a concentration of 10 mM in DMSO, unless stated otherwise. In high-throughput…
Tue, Jul 18, 2023
Can I customize the SCREEN-WELL® compound library I am interested in?
SCREEN-WELL® compound libraries can be customized to fit your experimental requirements (384-well plate, cherry-picking, smaller volume, etc.). Please feel free…
Tue, Jul 18, 2023
Which plates are used to package the SCREEN-WELL® compound libraries?
The SCREEN-WELL® compound libraries are packaged using deep-well 96-well plates from either Corning Costar (Prod. Ref. 3959) or Thermo Matrix…
Tue, Jul 18, 2023
General handling, storage instructions, and stability of the SCREEN-WELL® compound libraries
Compound libraries should be thawed at room temperature. Once thawed, the plates can be gently centrifuged to bring down any…
Tue, Jul 18, 2023
Can you please explain what the SCREEN-WELL® compound libraries are used for?
In general terms, a laboratory or company interested in high-throughput screening for drug discovery will have already established an assay…
Tue, Jul 18, 2023
