Home Shop 6-Formylindolo(3,2-b)carbazole

6-Formylindolo(3,2-b)carbazole

BML-GR206

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Ah receptor ligand

A tryptophan-derived, high affinity aryl hydrocarbon receptor ligand (K_d=7×10^-11 M). Proposed to be an endogenous AhR ligand. Induces rapid and transient expression of cytochrome P450-1A1 (CYP1A1) in human cells at 100 pM.

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Product Details

Alternative Name	FICZ
Appearance	Yellow solid.
CAS	172922-91-7
Couple Target	Ah receptor
Couple Type	Ligand
Formula	C₁₉H₁₂N₂O
MW	284.3
MeltingPoint	>300°C
Purity	≥95% (HPLC)
Solubility	Soluble in DMSO (10mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store solutions at -20°C for up to one month.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Regulation of the STAT3 pathway by lupus susceptibility gene Pbx1 in T cells: T. Roach, et al.; Mol. Immunol. 165, 1 (2024), Abstract
Bioluminescence imaging of Cyp1a1-luciferase reporter mice demonstrates prolonged activation of the aryl hydrocarbon receptor in the lung: Veland, N., Gleneadie, H. J., et al.; Commun. Biol. 7, 442 (2024), Abstract
Bioluminescence imaging ofCyp1a1-luciferase reporter mice demonstrates prolonged activation of the aryl hydrocarbon receptor in the lung: Veland, N., Gleneadie, H. J., et al.; bioRxiv , (2023)
Total parenteral nutrition impairs glucose metabolism by modifying the gut microbiome: P. Wang, et al.; Nat. Metab. 5, 331 (2023), Abstract
AhR Mediated Activation of Pro-Inflammatory Response of RAW 264.7 Cells Modulate the Epithelial-Mesenchymal Transition: P. Selvam, et al.; Toxics 10, 642 (2022), Abstract
Intestinal Stem Cells Damaged by Deoxycholic Acid via AHR Pathway Contributes to Mucosal Barrier Dysfunction in High-Fat Feeding Mice: Liu, L., Xu, J., et al.; Int. J. Mol. Sci. 23, (2022), Abstract
Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D: Kim, Y. S., Ko, B., et al.; Nat. Commun. 13, 6080 (2022), Abstract
Extensive Phenotype of Human Inflammatory Monocyte-Derived Dendritic Cells: F. Coutant, et al.; Cells 10, 1663 (2021), Abstract
AHR Regulates NK Cell Migration via ASB2-Mediated Ubiquitination of Filamin A: Shin, J. H., Moreno-Nieves, U. Y., et al.; Front. Immunol. 12, 624284 (2021), Abstract
Non-Genomic AhR-Signaling Modulates the Immune Response in Endotoxin-Activated Macrophages After Activation by the Environmental Stressor BaP: H. Großkop, et al.; Front. Immunol. 12, 620270 (2021), Abstract — Full Text