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Mitomycin C

BML-GR311

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DNA synthesis inhibitor

Antitumor antibiotic. DNA crosslinking and damaging agent. Inhibitor of DNA synthesis, nuclear division and cancer cells. DNA intercalating agent. Induces apoptosis in a variety of cells via a p53-dependent pathway.

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Product Details

Appearance	Blue-violet solid.
CAS	50-07-7
Couple Target	DNA
Couple Type	Ligand
Formula	C₁₅H₁₈N₄O₅
MI	14: 6215
MW	334.3
Purity	≥95% (HPLC)
RTECS	CN0700000
Solubility	Soluble in water (1mg/ml, warm), 100% ethanol (1mg/ml, warm), DMSO (15mg/ml) or methanol.
Technical Info / Product Notes	Note: Product is not sterile.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored at -20°C. Stock solutions in water or ethanol are stable for up to 1 week at -20°C. Stock solutions in DMSO are stable for up to 1 month at -20°C.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Survivin modulates stiffness-induced vascular smooth muscle cell motility: Mousso, T., Rice, K., et al.; APL Bioeng. 9, 026120 (2025), Abstract
Potent Omicron-neutralizing antibodies isolated from a patient vaccinated 6 months before Omicron emergence: Hastie, K. M., Yu, X., et al.; Cell Rep. 42, 112421 (2023), Abstract
Survivin as a mediator of stiffness-induced cell cycle progression and proliferation of vascular smooth muscle cells: J.C. Biber, et al.; APL Bioeng. 7, 046108 (2023), Abstract
Implications of the Wilms’ Tumor Suppressor Wt1 in Cardiomyocyte Differentiation: Wagner, N., Ninkov, M., et al.; Int. J. Mol. Sci. 22, (2021), Abstract
Relevance of Neurotrophin Receptors CD271 and TrkC for Prognosis, Migration, and Proliferation in Head and Neck Squamous Cell Carcinoma: Foerster, Y., Stöver, T., et al.; Cells 8, (2019), Abstract
Membrane-bound p35 Subunit of IL-12 on Tumor Cells is Functionally Equivalent to Membrane-bound Heterodimeric Single Chain IL-12 for Induction of Anti-tumor Immunity: H.J. Kim, et al.; Immune Netw. 16, 305 (2016), Application(s): Proliferation of ConA-activated splenocytes, Abstract — Full Text
Analogs of the novel phytohormone, strigolactone, trigger apoptosis and synergize with PARP inhibitors by inducing DNA damage and inhibiting DNA repair: Croglio, M. P., Haake, J. M., et al.; Oncotarget 7, 13984 (2016), Abstract
PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype: S. Duan, et al.0; Nat. Commun. 6, 10068 (2015), Application(s): Cell culture, MMC selectively killed PTEN-deficient NSCs, Abstract
Keratinocyte nicotinic acetylcholine receptor activation modulates early TLR2-mediated wound healing responses: M. Kishibe, et al.; Int. Immunopharmacol. 29, 63 (2015), Application(s): Cell Culture, Abstract
A small molecule with anticancer and antimetastatic activities induces rapid mitochondrial associated necrosis in breast cancer: A. Bastian, et al.; J. Pharmacol. Exp. Ther. 353, 392 (2015), Application(s): Assay, Abstract — Full Text