Cancer

Unraveling the Complex Landscape of Cancer

Cancer is the leading cause of death worldwide, accounting for nearly one in six deaths. In order to navigate the complex landscape of mutations and diverse types of genetic aberration that leads to cancer, the hallmarks of cancer were proposed as a set of functional capabilities acquired by human cells as normal cells transform into tumor cells in a multistage process that generally progresses from pre-cancerous lesion to a malignant tumor.

As cancer hallmarks have evolved over the last two decades so has our portfolio of tools to support cancer research. Over this time, we have called upon our diverse scientific and technical expertise to create innovative technologies, assays and reagents to aid with genomics, protein, cellular and tissue analysis, in addition to small molecules chemistry.

With our comprehensive catalog of unique products, we are committed to providing the tools and support you need to drive innovation and advancement in cancer and help discover the next hallmark.

Target Identification

Whether it’s a specific gene, protein, lipids or a whole pathway, target identification is one of the most critical steps in cancer research and drug discovery.

Genome instability and mutations are two of the most common causes of cancer. Fluorescence in situ hybridization (FISH) techniques provides a way to visualize and map the genetic material in individual cells. This is a very useful tool to understand a variety of chromosomal abnormalities and other genetic mutations.

Target Characterization

Some targets can play different roles depending
on the cell type or microenvironment,
hence, the characterization step is crucial for
the understanding of the functional role that
plays in normal cells vs cancer cells.
Cancer cells survive and adapt to many types of
stress, including hypoxia, nutrient deprivation,
metabolic, and oxidative stress.

Understanding the roles of DNA damage repairs in the promotion of cancer is essential for the development of targeted cancer therapy.

Exposure of cells to oxidative and environmental stresses frequently results in the breakdown of genomic DNA.

Target Analysis

Validation of the target is achieved with target analysis to understand and control its regulatory mechanism and the role that plays in the hallmarks of cancer.

Programmed cell death, such as apoptosis and autophagy, are regulated by a variety of biomacromolecures. Emerging evidence has revealed that programmed cell death are key features of tumorigenesis.

High quality biomarkers for cancer, especially antibodies, are crucial tools for prevention, diagnosis, prognostics, therapy and to effectively monitor treatment response after disease modifying treatments.

Enzo’s portfolio of antibodies for cancer research includes thousands of monoclonal and polyclonal antibodies validated for various applications, including immunohistochemistry (IHC), immunofluorescence (IF), flow cytometry and Western blotting.

Leverage over 45 years of innovation and technical expertise supporting drug development, discovery, research, and diagnostics through our core technology platforms. With over 150,000 citations, GMP and ISO certifications, our highly-sensitive, quality products consistently deliver trusted results. We maintain product integrity and reliability with our in-house U.S. manufacturing facility. We deploy our bench of expert PhD scientists to provide technical, tailored, support for our customers and their projects.

Rely on our extensive experience in innovation, technology development, and manufacturing to support your cancer research and development. Our comprehensive Life Sciences Contract Services support the development of customizable, unique, and efficient solutions for all your research needs.

Fighting Cancer with the Immune System

Immuno-oncology, also known as cancer immunotherapy, refers to the use of a person’s own immune system for the treatment of cancer. Research in the field includes:

• Targeting immune tolerance via co-inhibitory immune checkpoints
• Enhancing immune responses by costimulatory checkpoint pathways

At Enzo, our diverse scientific and technical expertise has helped us create innovative assays and reagents to help support cancer immunotherapy. We offer a complete set of solutions for Immuno-oncology research including antibodies, ELISA kits, and recombinant proteins.

Akt/PKB has emerged as a central player in the signal transduction pathways activated in response to growth factors or insulin. It is thought to contribute to several cellular functions including cell growth, transcriptional regulation, cell survival, and nutrient metabolism. It has been linked to a range of diseases including cancer and type II diabetes.

The Akt/PKB pathway is a popular target since it sits at the crossroads of both oncogenic and tumor suppressor signaling pathways. Enzo provides novel tools to help support cancer discovery from target selection, hit-to-lead discovery, and lead profiling.