Ephrin type-A receptor 6, also known as EphA6, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. It has been implicated in synapse formation and the regulation of synaptic function and plasticity. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). Ligand-mediated activation of Ephs induces various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer.
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