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MK-2206 . 2HCl

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Highly selective inhibitor of Akt1, Akt2 and Akt3

MK-2206 is a highly selective inhibitor of Akt1, Akt2 and Akt3 with IC₅₀ of 8 nM, 12 nM and 65 nM, respectively.

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Appearance	Yellow powder.
CAS	1032350-13-2
Couple Target	Akt
Couple Type	Inhibitor
Formula	C₂₅H₂₁N₅O . 2HCl
Identity	Determined by NMR
MW	480.4
Purity	≥99% (HPLC)
Solubility	Soluble in DMSO (14mg/ml) or ethanol (1mg/ml).

Use/Stability	As indicated on product label or CoA when stored as recommended.
Short Term Storage	+4°C
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

TXNIP mediates LAT1/SLC7A5 endocytosis to reduce amino acid uptake in cells entering quiescence: Kahlhofer, J., Marchet, N., et al.; bioRxiv , (2024)
Engagement of TREM2 by a novel monoclonal antibody induces activation of microglia and improves cognitive function in Alzheimer’s disease models: M. Fassler, et al.; J. Neuroinflammation 18, 19 (2021), Abstract — Full Text
EGFR-Pak Signaling Selectively Regulates Glutamine Deprivation-Induced Macropinocytosis: Lee, S. W., Zhang, Y., et al.; Dev. Cell 50, 381 (2019), Abstract
Integrin α7 Is a Functional Marker and Potential Therapeutic Target in Glioblastoma: Haas, T. L., Sciuto, M. R., et al.; Cell Stem Cell 21, 35 (2017), Abstract

Last modified: May 29, 2024

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