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p16^INK4a monoclonal antibody

ENZ-ABS377

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Monoclonal antibody to p16 for use with IHC applications

p16INK4a (p16, CDKN2A) is a tumor suppressor that inhibits the progression of the cell cycle through the G1 phase. p16 expression is associated with high-risk human papillomavirus in cervical cancer, and head and neck tumors. It is frequently deleted or mutated in tumors such as melanomas, gliomas, esophageal, pancreatic, lung, urinary bladder carcinomas, and some types of leukemias; making p16 a key marker for cancer research.

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This antibody is covered by our Worry-Free Guarantee.

p16INK4a monoclonal antibody Immunohistochemistry — Formalin-fixed paraffin-embedded cervical tissue stained using Enzo’s p16 antibody (ENZ-ABS377). IHC staining was performed on an automated Leica BOND III. Picture courtesy of Michael Priebs from Kantonsspital Aarau, Aarau, Switzerland.

p16INK4a monoclonal antibody (Ready-to-Use) image — Anal tissue incubated with p16INK4a monoclonal antibody and then stained with POLYVIEW® PLUS (anti-Mouse) HRP-DAB Kit (ENZ-KIT160).

p16INK4a monoclonal antibody (Ready-to-Use) Immunohistochemistry — Formalin-fixed paraffin-embedded tissue punch from HPV-positive cervical carcinoma stained using Enzo’s p16 antibody (ENZ-ABS377). IHC staining was performed on an automated Dako Autostainer Plus following antigen retrieval at high pH. Picture courtesy of Dr. Juana Maria Garcia Pedrero from Hospital Universitario Central de Asturias, Oviedo, Spain.

Product Details

Alternative Name	p16, Cyclin-dependent kinase inhibitor 2A
Application	IHC, WB
Application Notes	For IHC applications: Dilute the concentrate as appropriate in antibody diluent, and then apply 150 µL to the slide, as indicated in the user’s IHC protocol.
Formulation	Liquid. In Tris buffer, pH 7.5, containing 1% BSA and <0.1% sodium azide.
Host	Mouse
Immunogen	Recombinant p16.
Isotype	IgG
Purity Detail	Affinity-purified.
Recommendation Dilutions/Conditions	Immunohistochemistry (1:50-1:100)Optimal conditions must be determined individually for each application.
Species Reactivity	Human
UniProt ID	P51480
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Handling	Avoid freeze/thaw cycles.
Short Term Storage	+4°C
Long Term Storage	+4°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Human papillomavirus E6/E7 oncoproteins promote radiotherapy-mediated tumor suppression by globally hijacking host DNA damage repair.: Bruyere, D., Roncarati, P., et al.; Theranostics 13, 1130 (2023), Application(s): IHC, Abstract
Pathological characterization and clinical outcome of penile intraepithelial neoplasia variants: a North American series.: Straub Hogan, M. M., Spieker, A. J., et al.; Mod. Pathol. 35, 1101 (2022), Reactant(s): Human, Abstract
Comparative molecular analysis of testicular Leydig cell tumors demonstrates distinct subsets of neoplasms with aggressive histopathologic features: N.M. Rizzo, et al.; Mod. Pathol. 34, 1935 (2021), Abstract
The diagnostic utility of PRAME and p16 in distinguishing nodal nevi from nodal metastatic melanoma: S.H.C. Lee, et al.; Pathol. Res. Pract. 216, 153105 (2020), Abstract
Metastatic HPV-Associated Oropharyngeal Versus Primary Pulmonary Squamous Cell Carcinoma: is p16 Immunostain Useful?: Husain, A. N., Lingen, M. W., et al.; Head Neck Pathol. 14, 966 (2020), Reactant(s): Human, Abstract
Abstracts from USCAP 2020: Genitourinary Pathology (860-1046): ; Mod. Pathol. 33, 1002 (2020), Abstract
Abstracts from USCAP 2020: Genitourinary Pathology (860-1046): ; Lab. Invest. 100, 862 (2020), Abstract

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