AACOCF3

BML-ST335

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Inhibitor of PLA₂ and FAAH

AACOCF₃ is a trifluoromethylketone derivative of arachidonic acid. It is a selective inhibitor of human cytosolic PLA₂ and Ca²⁺-independent PLA₂ (iPLA₂, IC₅₀=15 µM). It is active in intact platelets and U937 cells (IC₅₀=8 µM). It also inhibits fatty acid amide hydrolase (100% at 7.5 µM).

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Product Details

Appearance	Yellow oil.
CAS	149301-79-1
Couple Target	FAAH, Phospholipase, PLA
Couple Type	Inhibitor
Formula	C₂₁H₃₁F₃O
Identity	Determined by NMR.
MW	356.5
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (>25mg/ml) or 100% ethanol (>25mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Solutions are stable for up to 1 month when stored under nitrogen or argon in tightly sealed container at -80°C.
Handling	Protect from air. Dissolve in solvent purged with nitrogen or argon. Store under nitrogen or argon in tightly sealed container.
Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Exocrine gland–resident memory CD8+ T cells use mechanosensing for tissue surveillance: N. Ruef, et al.; Sci. Immunol. 8, eadd5724 (2023), Abstract
PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma: Sarkar, C., Jones, J. W., et al.; Autophagy 16, 466 (2020), Abstract
Leukotriene D4-induced CaCo-2 cell proliferation is mediated by prostoglandin E2 synthesis: M. Cabral, et al.; Physiol. Rep. 3, e12417 (2015), Application(s): Cell culture , Abstract — Full Text
Molecular and behavioral characterization of adolescent protein kinase C following high dose ethanol exposure: Santerre, J. L., Gigante, E. D., et al.; Psychopharmacology (Berl.) 231, 1809 (2014), Abstract
CAY10593 inhibits the human P2X7 receptor independently of phospholipase D1 stimulation: Pupovac, A., Stokes, L., et al.; Purinergic Signal. 9, 609 (2013), Abstract
Role of phospholipase A₂ (PLA₂) inhibitors in attenuating apoptosis of the corneal epithelial cells and mitigation of Acanthamoeba keratitis: Tripathi, T., Abdi, M., et al.; Exp. Eye Res. 113, 182 (2013), Abstract
Inhibition of macrophage Ca(2+)-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones: E.J. Ackermann, et al.; J. Biol. Chem. 270, 445 (1995), Abstract
Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets: D. Riendeau, et al.; J. Biol. Chem. 269, 15619 (1994), Abstract
Tight binding inhibitors of 85-kDa phospholipase A2 but not 14-kDa phospholipase A2 inhibit release of free arachidonate in thrombin-stimulated human platelets: F. Bartoli, et al.; J. Biol. Chem. 269, 15625 (1994), Abstract
Inhibitors of arachidonoyl ethanolamide hydrolysis: B. Koutek, et al.; J. Biol. Chem. 269, 22937 (1994), Abstract

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AACOCF3

BML-ST335

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