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8-Bromo-cGMP

BML-CN205

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PKG activator

A cell-permeable cGMP analog which is more resistant to phosphodiesterases than cGMP and which preferentially activates cGMP-dependent protein kinase. It inhibits thrombin stimulated arachidonic acid release in human platelets.

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Product Details

Appearance	White to off-white powder
CAS	51116-01-9
Couple Target	PKG
Couple Type	Activator
Formula	C₁₀H₁₀BrN₅O₇PNa
Identity	Determined by ESI-MS and UV/VIS.
MW	446.1
Purity	≥96% (HPLC)
Solubility	Soluble in water (25mg/ml) or aqueous buffers. Sparingly soluble in methanol (4mM). Insoluble in DMSO, dimethyl formamide and 96% ethanol.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Endothelin-1 induces lipolysis through activation of the GC/cGMP/Ca2+/ERK/CaMKIII pathway in 3T3-L1 adipocytes: C.C. Lien, et al.; Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1867, 159071 (2022), Abstract
Lipid-Sorting Specificity Encoded in K-Ras Membrane Anchor Regulates Signal Output: Zhou, Y., Prakash, P., et al.; Cell 168, 239 (2017), Abstract
The nitric oxide–cyclic GMP pathway and synaptic depression in rat hippocampal slices: C.L. Boulton et al.; Eur. J. Neurosci. 6, 1528 (1994), Abstract
Nitric oxide in skeletal muscle: L. Kobizik et al.; Nature 372, 546 (1994), Abstract
Nitric oxide. More jobs for that molecule: S. Snyder; Nature 372, 504 (1994), Abstract
Cyclic GMP analogs inhibit gamma thrombin-induced arachidonic acid release in human platelets: D.C. Sane et al.; Biochem. Biophys. Res. Commun. 165, 708 (1989), Abstract
Relaxation of vascular and tracheal smooth muscle by cyclic nucleotide analogs that preferentially activate purified cGMP-dependent protein kinase: S.G. Francis et al.; Mol. Pharmacol. 34, 506 (1988), Abstract
Interaction of hydrolysis-resistant analogs of cyclic GMP with the phosphodiesterase and light-sensitive channel of retinal rod outer segments: A.L. Zimemmerman et al.; PNAS 82, 8813 (1985), Abstract
Sodium nitroprusside-induced protein phosphorylation in intact rat aorta is mimicked by 8-bromo cyclic GMP: R.M. Rapoport et al.; PNAS 79, 6470 (1982), Abstract
Relaxation of hormonally stimulated smooth muscular tissues by the 8-bromo derivative of cyclic GMP: K. D. Schultz et al.; Naunyn-Schmiedebergs Arch. Pharmacol. 306, 1 (1979), Abstract