Potent immunomodulator
Potent immunomodulator. Mediates a wide range of immune and inflammatory responses including the activation of B and T cells.
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Product Details
| Alternative Name |
IL-1F2, Interleukin-1β |
|---|---|
| Biological Activity |
Exerts in vitro biological activity in the range of 0.1-10ng/ml. |
| CAS |
97599-21-8 |
| Formulation |
Lyophilized. Salt-free. |
| MI |
14: 4993 |
| MW |
~17kDa. |
| Purity |
≥97% (SDS-PAGE) |
| Reconstitution |
Reconstitute with water, PBS or aqueous buffer to a concentration of 100µg/ml. For further dilution carrier protein (~1%) should be added to avoid loss of bioactivity. |
| Source |
Produced in E. coli. |
| Specific Activity |
≥1×107U/mg protein. Determined by proliferation assay using human TF-1 (T. Kitamura, et al.; Int. Immunol. 3, 571 (1991)). The ED50 for this effect is typically 0.2-2ng/ml. Results were compared with the international IL-1 reference standard preparation (WHO 86/680, NIBSC). |
| UniProt ID |
P01584 |
Handling & Storage
| Handling |
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C. |
|---|---|
| Long Term Storage |
-20°C |
| Shipping |
Ambient Temperature |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING: Aarreberg, L. D., Esser-Nobis, K., et al.; Mol. Cell 74, 801 (2019), Abstract
- An unexpected effect of TNF-α on F508del-CFTR maturation and function: S. Bitam, et al.; F1000Res 4, 218 (2015), Abstract — Full Text
- Expression of an uncleavable N-terminal RasGAP fragment in insulin-secreting cells increases their resistance toward apoptotic stimuli without affecting their glucose-induced insulin secretion: J.Y. Yang, et al.; J. Biol. Chem. 280, 32835 (2005), Abstract
Related Products
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|---|---|
| Purity | ≥95% (SDS-PAGE) |
| Source | Produced in HEK 293 cells. The cysteine-rich region of human CD134 (OX40) (aa 29-214) is fused to the Fc portion of human IgG1. |
| Alternative Name | OX40L, TNFSF 4, CD252 |
|---|---|
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| Alternative Name | 4-1BB, TNFRSF 9 |
|---|---|
| Purity | ≥95% (SDS-PAGE) |
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| Alternative Name | 4-1BBL, TNFSF 9 |
|---|---|
| Purity | ≥85% (SDS-PAGE) |
| Source | Produced in HEK 293 cells. The extracellular domain of human CD137L (aa 49-254) is fused at the N-terminus to a linker peptide (10 aa) and a FLAG®-tag. |
Last modified: May 29, 2024
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