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Colcemid

ALX-430-033

15 citations

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Depolymerizes microtubules and inhibits their formation. Induces apoptosis.

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Product Details

Alternative Name	Demecolcine
Appearance	Light yellow powder.
CAS	477-30-5
Formula	C₂₁H₂₅NO₅
Identity	Determined by 1H-NMR and TLC.
MI	14: 2887
MW	371.4
Purity	≥98% (HPLC)
Solubility	Soluble in 100% ethanol, chloroform or DMSO.
Source	Semisynthetic from colchicine (Prod. No. ALX-380-033).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stock solutions are stable for at least 6 months when stored at -20°C.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation: W. Li, et al.; Nat. Commun. 13, 7414 (2022), Abstract
The asymmetrically segregating lncRNA cherub is required for transforming stem cells into malignant cells: Landskron, L., Steinmann, V., et al.; Elife 7, (2018), Abstract
Independent modes of ganglion cell translocation ensure correct lamination of the zebrafish retina: Icha, J., Kunath, C., et al.; J. Cell Biol. 215, 259 (2016), Abstract
Kinesin molecular motor Eg5 functions during polypeptide synthesis: Bartoli, K. M., Jakovljevic, J., et al.; Mol. Biol. Cell 22, 3420 (2011), Abstract
Spontaneous chromosome loss and colcemid resistance in lymphocytes from patients with myotonic dystrophy type 1: M. Casella, et al.; Cytogenet. Genome Res. 100, 224 (2003), Abstract
Expression of apoptosis and cell cycle related genes in proliferating and colcemid arrested cells of divergent lineage: B.W. Gallaher, et al.; Cell. Mol. Biol. 46, 79 (2000), Abstract
Protein phosphatase-1 activation and association with the retinoblastoma protein in colcemid-induced apoptosis: F. Puntoni & E. Villa-Moruzzi; BBRC 266, 279 (1999), Abstract
Colcemid-induced apoptosis of cultured human glioma: electron microscopic and confocal laser microscopic observation of cells sorted in different phases of cell cycle: T. Tsuchida, et al.; Cytometry 31, 295 (1998), Abstract
Dissociation of nuclear and cytoplasmic cell cycle progression by drugs employed in cell synchronization: L. Urbani, et al.; Exp. Cell. Res. 219, 159 (1995), Abstract
Effects of colcemid concentration on chromosome aberration analysis in human lymphocytes: R. Kanda, et al.; J. Radiat. Res. (Tokyo) 35, 41 (1994), Abstract

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Colcemid

ALX-430-033

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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