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Thiostrepton

ALX-380-261

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Elongation factor G inhibitor

Thiazole-containing peptide antibiotic. Inhibits protein synthesis by preventing binding of GTP to the 50S ribosomal subunit. Inhibits binding of elongation factor G (EF-G) and the dissociation of EF-G from the ribosome.

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Product Details

Activity	≥900 U/mg
Appearance	White to off-white solid.
CAS	1393-48-2
Couple Target	Elongation factor, Ribosome
Couple Type	Inhibitor, Ligand
Formula	C₇₂H₈₅N₁₉O₁₈S₅
MI	14: 9364
MW	1664.9
RTECS	XN6300100
Solubility	Soluble in acetic acid, DMSO (10mg/ml) or dimethyl formamide; insoluble in water.
Source	Isolated from Streptomyces azureus.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light and moisture.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Effects of thiostrepton alone or in combination with selumetinib on triple-negative breast cancer metastasis: F.D. Korkmaz, et al.; Mol. Biol. Rep. 49, 10387 (2022), Abstract
Forkhead Box Protein M1 Promotes Nasopharyngeal Carcinoma Cell Tumorigenesis Possibly via the Wnt/β-Catenin Signaling Pathway: Yu, C., Chen, H., et al.; Med. Sci. Monit. 27, e931970 (2021), Abstract
In vivo assembling of bacterial ribosomal protein L11 into yeast ribosomes makes the particles sensitive to the prokaryotic specific antibiotic thiostrepton: A. Garcia-Marcos, et al.; Nucl. Acids Res. 35, 7109 (2007), Abstract — Full Text
Interaction of thiostrepton and elongation factor-G with the ribosomal protein L11-binding domain: W.S. Bowen, et al.; J. Biol. Chem. 280, 2934 (2005), Abstract — Full Text
Interactions of the N-terminal domain of ribosomal protein L11 with thiostrepton and rRNA: S.L. Bausch, et al.; J. Biol. Chem. 280, 29956 (2005), Abstract — Full Text
Thiostrepton inhibits the turnover but not the GTPase of elongation factor G on the ribosome: M.V. Rodnina, et al.; PNAS 96, 9586 (1999), Abstract — Full Text
The antibiotics micrococcin and thiostrepton interact directly with 23S rRNA nucleotides 1067A and 1095A: G. Rosendahl & S. Douthwaite; Nucl. Acids Res. 22, 357 (1994), Abstract — Full Text
Characterization of an 8.7-kilobase thiostrepton resistance-encoding plasmid (pGIF3) of Streptomyces incarnatus: H. Malina & M. Robert-Gero; Appl. Environ. Microbiol. 58, 895 (1992), Abstract — Full Text
Recognition of the highly conserved GTPase center of 23 S ribosomal RNA by ribosomal protein L11 and the antibiotic thiostrepton: P.C. Ryan, et al.; J. Mol. Biol. 221, 1257 (1991), Abstract
Alpha-sarcin cleavage of ribosomal RNA is inhibited by the binding of elongation factor G or thiostrepton to the ribosome: S.P. Miller & J.W. Bodley; Nucl. Acids Res. 19, 1657 (1991), Abstract — Full Text