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Vinblastine . sulfate

ALX-350-257

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Cell cycle blocker

Plant alkaloid that arrests the cell cycle in G2/M phase by blocking mitotic spindle formation. Inhibits normal microtubule asembly and causes aberant tubulin polymerization. Blocks binding of tubulin to microtubule proteins. Induces apoptosis. Triggers Raf-1 activation, phosphorylation of Bcl-2 family proteins and induction of p53 expression. Cancer chemotherapeutic agent.

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Product Details

Alternative Name	Vincaleukoblastine . sulfate
Appearance	White to light yellow crystalline powder.
CAS	143-67-9
Formula	C₄₆H₅₈N₄O₉ . H₂SO₄
MI	14: 9982
MW	909.1
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO, methanol or water (25mg/ml).
Source	Semisynthetic from catharanthine or vindoline.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

PARP3 supervises G9a-mediated repression of adhesion and hypoxia-responsive genes in glioblastoma cells: L.N. Zebaze, et al.; Sci. Rep. 12, 15534 (2022), Abstract
Attenuation of Colchicine Toxicity in Drug-resistant Cancer Cells by Co-treatment with Anti-malarial Drugs: A.R. Choi, et al.; Anticancer Res. 36, 5859 (2016), Application(s): Cell treatment with KBV20C cells, Abstract — Full Text
Co-treatment with Celecoxib or NS398 Strongly Sensitizes Resistant Cancer Cells to Antimitotic Drugs Independent of P-gp Inhibition: J.S. Lim, et al.; Anticancer Res. 36, 5063 (2016), Application(s): Cell Treatment, Abstract — Full Text
PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug: T. He, et al.; J. Exp. Clin. Cancer Res. 34, 152 (2015), Application(s): Cell culture, Abstract — Full Text
Vinblastine, a chemotherapeutic drug, inhibits palmitoylation of tubulin in human leukemic lymphocytes: J.M. Caron & M. Herwood; Chemotherapy 53, 51 (2007), Abstract
Vinblastine-induced phosphorylation of Bcl-2 and Bcl-XL is mediated by JNK and occurs in parallel with inactivation of the Raf-1/MEK/ERK cascade: M. Fan, et al.; J. Biol. Chem. 275, 29980 (2000), Abstract — Full Text
Use of drugs to study role of microtubule assembly dynamics in living cells: A. Jordan & L. Wilson; Meth. Enzymol. 298, 252 (1998), Abstract
Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle: A. Jordan, et al.; Med. Res. Rev. 18, 259 (1998), Abstract
The C terminus of beta-tubulin regulates vinblastine-induced tubulin polymerization: S.S. Rai & J. Wolff; PNAS 95, 4253 (1998), Abstract — Full Text
Caspase-3 activation is not responsible for vinblastine-induced Bcl-2 phosphorylation and G2/M arrest in human small cell lung carcinoma Ms-1 cells: E. Tashiro, et al.; Jpn. J. Cancer Res. 89, 940 (1998), Abstract

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Vinblastine . sulfate

ALX-350-257

Product Details

Handling & Storage

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