Pepstatin A (synthetic)

ALX-260-085

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Protease inhibitor

Inhibitor of aspartate (acid) proteases, including pepsin, cathepsin D, renin, chymosin, bacterial aspartic proteinases and HIV proteases. Efficiently inhibits Fcγ receptor induction by IFN-γ. Blocks the endocytic pathway followed by an antibody when it enters the cell at the level of early endosomal compartments, resulting in inhibition of autoantigen presentation or viral transmission. Suppresses p-53-dependent apoptosis in lymphoid cells as well as TNFα-induced apoptosis in U937 cells. Inhibits degradation of autophagic cargo inside autophagolysosomes.

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Product Details

Alternative Name	Iva-Val-Val-Sta-Ala-Sta, i-Valeryl-L-Val-L-Val-AHMHA-L-Ala-AHMHA
Appearance	White to off-white solid.
CAS	26305-03-3
Formula	C₃₄H₆₃N₅O₉
MI	14: 7147
MW	685.9
Purity	≥98% (HPLC)
RTECS	SC6155000
Sequence	i-Valeryl-L-Val-L-Val-AHMHA-L-Ala-AHMHA (AHMHA = (3S,4S)-4-Amino-3-hydroxy-6-methyl-heptanoic acid)
Solubility	Soluble in DMSO (10mg/ml), methanol (1mg/ml) or acetic acid.
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 2 years after receipt when stored at -20°C.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Neuronal autosis is Na+/K+-ATPase alpha 3-dependent and involved in hypoxic-ischemic neuronal death: Depierre, P., Ginet, V., et al.; Cell Death Dis. 15, 363 (2024), Abstract
Inhibition of striatonigral autophagy as a link between cannabinoid intoxication and impairment of motor coordination: C. Blázquez, et al.; Elife 9, 5681 (2021), Abstract — Full Text
Optimized Incorporation of Alkynyl Fatty Acid Analogs for the Detection of Fatty Acylated Proteins using Click Chemistry: L.M.Q. Liao, et al.; J. Vis. Exp. , (2021), Abstract
A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol: Fessler, E., Eckl, E. M., et al.; Nature 579, 433 (2020), Abstract
Induction of Lysosomal Membrane Permeabilization Is a Major Event of FTY720-Mediated Non-Apoptotic Cell Death in Human Glioma Cells: M.B. Reis, et al.; Nat. Commun. 11, 5433 (2020), Abstract — Full Text
Anti-cancer potential of persimmon (Diospyros kaki) leaves via the PDGFR-Rac-JNK pathway: H. Kim, et al.; Sci. Rep. 10, 18119 (2020), Abstract — Full Text
Lysosomal dysfunction and autophagy blockade contribute to MDMA-induced neurotoxicity in SH-SY5Y neuroblastoma cells: I.H. Li, et al.; Chem. Res. Toxicol. 33, 903 (2020), Abstract
Regulation of Autophagic Flux by the 20S Proteasome: Njomen, E., Tepe, J. J., et al.; Cell Chem. Biol. 26, 1283 (2019), Abstract
Expression and Purification of a Mammalian P2X7 Receptor from Sf9 Insect Cells: A. Karasawa, et al.; Bio Protoc. 7, e2544 (2017), Abstract — Full Text
Inhibition of Cyclic Adenosine Monophosphate-Specific Phosphodiesterase by Various Food Plant-Derived Phytotherapeutic Agents: T. Röhrig, et al.; Medicines (Basel) 4, 80 (2017), Abstract — Full Text