AMPIVIEW® RNA probes
Enabling Your Projects 
GMP Services
Bulk Solutions
Research Travel Grant
Have You Published Using an Enzo Product?
Lysosome-associated membrane proteins (LAMP1 and LAMP2) are type I integral membrane protein that are transported from the trans-Golgi network to endosomes and then lysosomes. Following activation of platelets, T-cells, neutrophils, or endothelium, LAMP1 and LAMP2 are expressed on the cell surface. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, and loss of LAMP2 expression is associated with impaired autophagy observed in Danons disease.
Shipping: Available products typically ship within 24/48h, via priority shipping.
Do you need support? Contact Customer Service or Technical Support.
Online Account
Access or Create Your Account
This antibody is covered by our Worry-Free Guarantee.
Immunocytochemistry analysis of CHO K1 cells incubated with LAMP1, mAb (Ly1C6) at 1:100 and goat anti-mouse Alexa 488 secondary antibody (Image provided by Dr. Guy Groblewski, University of Wisconsin-Madison).
Product Details
| Alternative Name |
Lysosomal-associated membrane protein 1 |
|---|---|
| Application |
Electron microscopy, ICC, IF, IP, WB |
| Application Notes |
Detects a band of ~120kDa by Western blot. |
| Clone |
LY1C6 |
| Formulation |
Liquid. In PBS containing 50% glycerol and 0.09% sodium azide. |
| GenBank ID |
M34959 |
| Host |
Mouse |
| Immunogen |
Rat liver lysosomal membrane preparation. |
| Isotype |
IgG1 |
| Purity Detail |
Protein G affinity purified. |
| Recommendation Dilutions/Conditions |
Immunocytochemistry (1:100)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. |
| Source |
Purified from ascites. |
| Species Reactivity |
Hamster, Human, Rat |
| UniProt ID |
P14562 |
| Worry-free Guarantee |
This antibody is covered by our Worry-Free Guarantee. |
Handling & Storage
| Handling |
Avoid freeze/thaw cycles. |
|---|---|
| Long Term Storage |
-20°C |
| Shipping |
Blue Ice |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Bcl-xL overexpression in T cells preserves muscle mitochondrial structure and function and prevents frailty in old mice: Mas-Bargues, C., Román-Domínguez, A., et al.; Sci. Adv. 11, eadr1378 (2025), Abstract
- Collapse of late endosomal pH elicits a rapid Rab7 response via the V-ATPase and RILP: Mulligan, R. J., Magaj, M. M., et al.; J. Cell Sci. 137, jcs261765 (2024), Abstract
- Development of Genetically Encoded Fluorescent KSR1-Based Probes to Track Ceramides during Phagocytosis: Girik, V., van Ek, L., et al.; Int. J. Mol. Sci. 25, (2024), Abstract
- The Endolysosomal Transporter DMT1 is Required for Morphine Regulation of Neuronal Ferritin Heavy Chain: Irollo, E., Nash, B., et al.; J. Neuroimmune Pharmacol. 18, 495 (2023), Abstract
- Molecular determinants of the crosstalk between endosomal microautophagy and chaperone-mediated autophagy: Krause, G. J., Kirchner, P., et al.; Cell Rep. 42, 113529 (2023), Abstract
- Disruption of Golgi markers by two RILP-directed shRNAs in neurons: A new role for RILP or a neuron-specific off-target phenotype?: Yap, C. C., Digilio, L., et al.; J. Biol. Chem. 299, 104916 (2023), Abstract
- Collapse of late endosomal pH elicits a rapid Rab7 response via V-ATPase and RILP: Mulligan, R. J., Magaj, M. M., et al.; bioRxiv , (2023)
- Antiretroviral treatment reveals a novel role for lysosomes in oligodendrocyte maturation: Festa, L. K., Clyde, A. E., et al.; J. Neurochem. 165, 722 (2023), Abstract
- The US9-Derived Protein gPTB9TM Modulates APP Processing Without Targeting Secretase Activities.: Brandimarti, R., Irollo, E., et al.; Mol. Neurobiol. 60, 1811 (2023), Application(s): ICC-IF / Reactant(s): Human, Abstract
- DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting: C.J. Yuskaitis, et al.; Cell Rep. 40, 111278 (2022), Application(s): ICC-IF, Abstract
- Dynein Is Required for Rab7-Dependent Endosome Maturation, Retrograde Dendritic Transport, and Degradation.: Yap, C. C., Digilio, L., et al.; J. Neurosci. 42, 4415 (2022), Reactant(s): Mouse, Abstract
- Tau seeds are subject to aberrant modifications resulting in distinct signatures: Tseng, J. H., Ajit, A., et al.; Cell Rep. 35, 109037 (2021), Abstract
- Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration: Socodato, R., Portugal, C. C., et al.; Cell Rep. 31, 107796 (2020), Abstract
- Alzheimer Aβ Assemblies Accumulate in Excitatory Neurons upon Proteasome Inhibition and Kill Nearby NAKα3 Neurons by Secretion.: Komura, H., Kakio, S., et al.; iScience 13, 452 (2019), Application(s): ICC / Reactant(s): Rat, Abstract
- WHAMM initiates autolysosome tubulation by promoting actin polymerization on autolysosomes: Dai, A., Yu, L., et al.; Nat. Commun. 10, 3699 (2019), Abstract
- Degradation of dendritic cargos requires Rab7-dependent transport to somatic lysosomes: C.C. Yap, et al.; J. Cell Biol. 217, 3141 (2018), Application(s): ICC-IF / Reactant(s) Rat, Abstract — Full Text
- Visualizing BDNF cell-to-cell transfer reveals astrocytes are the primary recipient of neuronal BDNF: Kügler, S., Dean, C., et al.; bioRxiv , (2018), Application(s): ICC
- Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization.: Fukata, M., Hoogenraad, C. C., et al.; Neuron 94, 809 (2017), Application(s): ICC-IF / Reactant(s): Rat, Abstract
- The endosomal neuronal proteins Nsg1/NEEP21 and Nsg2/P19 are itinerant, not resident proteins of dendritic endosomes: C.C. Yap, et al.; Sci. Rep. 7, 10481 (2017), Application(s): IF, Abstract — Full Text
- A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes: A.C. Wolfes, et al.; J. Gen Physiol. 149, 149 (2017), Application(s): ICC / Reactant(s) Rat, Abstract — Full Text
- SNX27 and SORLA Interact to Reduce Amyloidogenic Subcellular Distribution and Processing of Amyloid Precursor Protein: Huang, T. Y., Zhao, Y., et al.; J. Neurosci. 36, 7996 (2016), Abstract
- Micellar nanocomplexes for biomagnetic delivery of intracellular proteins to dictate axon formation during neuronal development: G. Suarato, et al.; Biomaterials 112, 176 (2016), Application(s): Examination of NCs localization following uptake, Abstract
- The novel monoclonal antibody 9F5 reveals expression of a fragment of GPNMB/osteoactivin processed by furin-like protease(s) in a subpopulation of microglia in neonatal rat brain: K. Kawahara, et al.; Glia 64, 1938 (2016), Application(s): Immunocytochemical Analysis, Abstract — Full Text
- Rab27A Is Present in Mouse Pancreatic Acinar Cells and Is Required for Digestive Enzyme Secretion: Y. Hou, et al.; PLoS One 10, e0125596 (2015), Reactant(s) Mouse, Abstract — Full Text
- Activity-Dependent Ubiquitination of GluA1 and GluA2 Regulates AMPA Receptor Intracellular Sorting and Degradation: Widagdo, J., Chai, Y. J., et al.; Cell Rep. 10, 783 (2015), Abstract
- Shank2 Regulates Renal Albumin Endocytosis: Dobrinskikh, E., Lewis, L., et al.; Physiol. Rep. 3, (2015), Abstract
- Acute mechanisms underlying antibody effects in anti-N-methyl-D-aspartate receptor encephalitis: E.H. Moscato, et al.; Ann. Neurol. 76, 108 (2014), Application(s): ICC / Reactant(s) Rat, Abstract — Full Text
- Human podocytes perform polarized, caveolae-dependent albumin endocytosis: Dobrinskikh, E., Okamura, K., et al.; Am. J. Physiol. Renal Physiol. 306, F941 (2014), Abstract
- STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy: J.V. Ferreira, et al.; Autophagy 9, 1349 (2013), Abstract
- Expression of OA1 limits the fusion of a subset of MVBs with lysosomes – a mechanism potentially involved in the initial biogenesis of melanosomes: Burgoyne, T., Jolly, R., et al.; J. Cell Sci. 126, 5143 (2013), Abstract
- Clathrin and phosphatidylinositol-4,5-bisphosphate regulate autophagic lysosome reformation: Y. Rong, et al.; Nat. Cell Biol. 14, 924 (2012), Abstract
- Tumor protein D52 expression and Ca2+-dependent phosphorylation modulates lysosomal membrane protein trafficking to the plasma membrane: D.D. Thomas, et al.; Am. J. Physiol. Cell Physiol. 298, C725 (2010), Application(s): ICC in CHO-K1 cells, Abstract — Full Text
- Constitutive, agonist-accelerated, recycling and lysosomal degradation of GABA(B) receptors in cortical neurons: D. Benke, et al.; Mol. Cell. Neurosci. 39, 628 (2008), Application(s): IF using rat tissue culture, Abstract
- ARAP1 Regulates EGF Receptor Trafficking and Signalling: T. Daniele, et al.; Traffic 9, 2221 (2008), Application(s): EM using rat cell lysates, Abstract
- The H+-coupled electrogenic lysosomal amino acid transporter LYAAT1 localizes to the axon and plasma membrane of hippocampal neurons: R.H. Edwards, et al.; J. Neurosci. 23, 1265 (2003), Application(s): ICC using rat samples, Abstract
- Synapse-associated protein97 selectively associates with a subset of AMPA receptors early in their biosynthetic pathway: R.J. Wenthold, et al.; J. Neurosci. 21, 7506 (2001), Application(s): ICC using rat samples, Abstract
- 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) causes Akt phosphorylation and morphological changes in intracellular organellae in cultured rat astrocytes: M. Michikawa, et al.; J. Neurochem. 77, 274 (2001), Application(s): ICC using rat samples, Abstract
- Transport of the lysosomal membrane glycoprotein lgp120 (lgp-A) to lysosomes does not require appearance on the plasma membrane: C. Harter & I. Mellman; J. Cell Biol. 117, 311 (1992), Application(s): ICC using rat samples, Abstract
- Glycoproteins of the lysosomal membrane: V. Lewis, et al.; J. Cell Biol. 100, 1839 (1985), Application(s): ICC, IP using rat samples, Abstract
Datasheet, Manuals, SDS & CofA
Manuals And Inserts
Certificate of Analysis
Please enter the lot number as featured on the product label
SDS
Enzo Life Science provides GHS Compliant SDS
If your language is not available please fill out the SDS request form