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Grp75/Mortalin monoclonal antibody (30A5)

ADI-SPS-825

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Grp75 (Glucose regulated 75 kDa protein) is a member of the Hsp70 family. It is localized in the mitochondrial matrix, where, in concert with Hsp60, is thought to participate in the re-folding of proteins translocated into this organelle. Like its E. coli homolog DnaK, Grp75 possesses a cation-dependent ATPase activity thought to be central to its function as a chaperone.

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This antibody is covered by our Worry-Free Guarantee.

Grp75/Mortalin monoclonal antibody (30A5) Immunohistochemistry — Immunohistochemistry analysis of human breast cancer tissue immunohistochemically stained using Grp75 mAb (30A5).

Grp75/Mortalin monoclonal antibody (30A5) Western blot — Western blot analysis of Grp75/Mortalin, mAb (30A5) (Prod. no. ADI-SPS-825): Lane 1: MW marker; Lane 2: HeLa (heat shocked); Lane 3: L-929 (heat shocked); Lane 4: CHO -K1 (heat shocked); Lane 5: GPC-16 (heat shocked); Lane 6: PC-12 (heat shocked).

Product Details

Alternative Name	MtHsp70, Hsp70 (mitochondrial), HspA9
Application	IHC, WB
Application Notes	Detects a band of ~75kDa by Western blot.
Clone	30A5
Formulation	Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
GenBank ID	L15189
Host	Mouse
Immunogen	Native human Grp75 (Mortalin).
Isotype	IgG1
Purity Detail	Ammonium sulfate precipitation purified.
Recommendation Dilutions/Conditions	Immunohistochemistry (1:50)Western Blot (1:1,000, colorimetric)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.
Source	Purified from mouse ascites.
Species Reactivity	Bovine, Chicken, Dog, Drosophila, Guinea pig, Hamster, Human, Monkey, Mouse, Porcine, Rabbit, Rat, Sheep, Xenopus
UniProt ID	P38646
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Handling	Avoid freeze/thaw cycles.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

The UPRmt preserves mitochondrial import to extend lifespan.: Xin, N., Durieux, J., et al.; J. Cell Biol. 221, (2022), Application(s): WB, Abstract
The UPRsup>mt/sup> Preserves Mitochondrial Import to Extend Lifespan: Xin, N., Durieux, J., et al.; bioRxiv , (2020)
Mortalin is Expressed by Astrocytes and Decreased in the Midbrain of Parkinson’s Disease Patients: Cook, T. J., Hoekstra, J. G., et al.; Brain Pathol. 26, 75 (2016), Abstract
Dysregulation of mitochondrial quality control processes contribute to sarcopenia in a mouse model of premature aging.: Joseph, A. M., Leeuwenburgh, C., et al.; PLoS One 8, e69327 (2013), Application(s): WB / Reactant(s): Mouse, Abstract
Toxic Memory’ via chaperone modification is a potential mechanism for rapid Mallory-Denk body reinduction: M. Omary, et al.; Hepatology 48, 931 (2008), Application(s): WB using mouse tissue, Abstract

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