Osteopontin (human), ELISA kit

• Tested – thoroughly validated in plasma, urine, and milk
• Fast – results in just 3 hours from up to 41 samples in duplicate
• Trusted – data correlating assay results to cancer patient survival published in peer-reviewed journals
• Reliable – reproducible results day-after-day and lot-after-lot
• Convenient – ready-to-use pre-coated plates and liquid color-coded reagents reduce errors

The Osteopontin (human), EIA kit is a colorimetric immunometric enzyme immunoassay kit with results in 3 hours. Absorbance is read at 405 nm. Ready-to-use liquid color-coded reagents reduce error. Excellent publications in peer-reviewed publications demonstrate the utility and consistency of this kit developed with highly cited double monoclonal antibodies.

Osteopontin (OPN) is an acidic extracellular matrix cell adhesion protein that is relatively abundant not only in bone matrix, plasma, urine, and milk, but is also found in malignant and atherogenic tissues. Phosphorylation, glycosylation and calcium modifications allow intact and fragmented Osteopontin to direct a variety of diverse responses including tissue remodeling, inflammation and cell survival. Plasma Osteopontin has been shown to be a positive indicator of colon and lung cancers as well as metastatic carcinomas. The notable presence of Osteopontin in a variety of tumors is strongly correlated to pathological stage, suggesting its critical role in tumor invasiveness, progression and metastasis. In addition, Osteopontin inhibits inducible nitric oxide synthase activity, thereby protecting tumor cells from NO-mediated macrophage cytotoxic attack. Osteopontin is found in atherosclerotic plaques and may drive a number of diabetic vascular pathologies.