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The IL-6 (mouse), ELISA kit is a colorimetric immunometric enzyme immunoassay kit
- Results in <3 hours
- Sensitive to 1.01 pg/mL
- Measure up to 36 samples per 96 well plate
- Ready-to-use reagents and pre-coated plates reduce errors and save your time
The IL-6 (mouse), EIA kit is a colorimetric immunometric enzyme immunoassay kit with results in < 3 hours.
Interleukin-6 (IL-6) is a cytokine critical to the regulation of the immune and hematopoietic systems. Human IL-6 is expressed by T-cells, mast cells, monocytes, macrophages, fibroblasts, endothelial cells, keratinocytes, and many tumor cell lines. It appears to take part in acute phase reactions and response to injury and inflammation. Human IL-6 also stimulates the differentiation of B-cells for antibody production, promotes expansion of activated T-cells, expands hematopoietic cell production, and induces the expression of acute phase proteins.
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IL-6 (mouse), ELISA kit Kit graph
Product Details
| Alternative Name |
Interleukin-6 |
|---|---|
| Application |
Colorimetric detection, ELISA |
| Application Notes |
For the quantitative determination of mouse Il-6 in culture supernatants and serum. Cited sample type includes tissue. |
| Assay Time |
<3 hours |
| Compatibility |
This product is compatible with the Absorbance 96 Plate Reader. |
| Contents |
Microtiter plate, Conjugate, Antibody, Assay buffer 13, Wash buffer concentrate, Standard, TMB Substrate, Stop solution |
| Sensitivity |
1.01 pg/ml (range 7.81-1,000 pg/ml) |
| Species Reactivity |
Mouse |
| Technical Info / Product Notes |
Cited samples: |
| UniProt ID |
P08505 |
| Wavelength |
450 nm |
Handling & Storage
| Use/Stability |
Store all components at 4°C, except standard at -20°C. |
|---|---|
| Shipping |
Dry Ice |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Mimicking immune complexes for efficient antibody responses: Schönfelder, J., El Ayoubi, O., et al.; Front. Immunol. 16, 1570487 (2025), Abstract
- Generation of a mouse model of thyroid storm induced by exogenous thyrotoxicosis and lipopolysaccharide: preliminary investigation of the therapeutic effects of ghrelin: Kurimoto, C., Furukawa, Y., et al.; Research Square , (2024)
- Generation of a mouse model of thyroid storm and preliminary investigation of the therapeutic effects of ghrelin: Kurimoto, C., Furukawa, Y., et al.; BMC Endocr. Disord. 24, 150 (2024), Abstract
- Anti-inflammatory effects of new human histamine H3 receptor ligands with flavonoid structure on BV-2 neuroinflammation: Honkisz-Orzechowska, E., Popiołek-Barczyk, K., et al.; Inflamm. Res. 72, 181 (2023), Abstract
- A Multitarget Approach against Neuroinflammation: Alkyl Substituted Coumarins as Inhibitors of Enzymes Involved in Neurodegeneration: E. Berrino, et al.; Antioxidants 12, 2044 (2023), Abstract
- Exploring the therapeutic efficacy of Chlorella pyrenoidosa peptides in ameliorating Alzheimer’s disease: S.M. Wang, et al.; Heliyon 9, e15406 (2023), Abstract
- Tumor Necrosis Factor-α Mediates Lung Injury in the Early Phase of Endotoxemia: K.Y. Chen, et al.; Pharmaceuticals 15, 287 (2022), Abstract
- Quercetin-Rich Ethanolic Extract of Polygonum odoratum var Pakphai Leaves Decreased Gene Expression and Secretion of Pro-Inflammatory Mediators in Lipopolysaccharide-Induced Murine RAW264.7 Macrophages: Chansiw, N., Champakam, S., et al.; Molecules 27, (2022), Abstract
- Prunetinoside Inhibits Lipopolysaccharide-Provoked Inflammatory Response via Suppressing NF-κB and Activating the JNK-Mediated Signaling Pathway in RAW264.7 Macrophage Cells: Abusaliya, A., Bhosale, P. B., et al.; Int. J. Mol. Sci. 23, (2022), Abstract
- Serum biomarkers based neurotrauma severity scale: a study in the mice model of fluid percussion injury: M. Aleem, et al.; Acta Neurobiol. Exp. (Wars.) 82, 147 (2022), Abstract
- Specialized Pro-Resolving Mediators Do Not Inhibit the Synthesis of Inflammatory Mediators Induced by Tumor Necrosis Factor-α in Synovial Fibroblasts: Y. Sueda, et al.; Yonoago Acta Med. 65, 111 (2022), Abstract
- Differential Immunometabolic Effects of High-Fat Diets Containing Coconut, Sunflower, and Extra Virgin Olive Oils in Female Mice: C.R. García, et al.; Mol. Nutr. Food Res. 66, e2200082 (2022), Abstract
- Skin Dryness Induced in the KK-Ay/TaJcl Type 2 Diabetes Mouse Model Deteriorates Following Dapagliflozin Administration: T. Horikawa, et al.; Biol. Pharm. Bull. 45, 934 (2022), Abstract
- 4-Phenylbutyric acid, a potent endoplasmic reticulum stress inhibitor, attenuates the severity of collagen-induced arthritis in mice via inhibition of proliferation and inflammatory responses of synovial fibroblasts: Y. Choi, et al.; Kaohsiung J. Med. Sci. 37, 604 (2021), Application(s): IL-6 quantification in mouse blood, Abstract
- BACH1 is transcriptionally inhibited by TET1 in hepatocellular carcinoma in a microRNA-34a-dependent manner to regulate autophagy and inflammation: X. Sun, et al.; Pharmacol. Res. 169, 105611 (2021), Abstract
- Simultaneous Inhibition of Three Major Cytokines and Its Therapeutic Effects: A Peptide-Based Novel Therapy against Endotoxemia in Mice: H. U. Shih, et al.; J. Pers. Med. 11, 436 (2021), Abstract
- Screening of Anti-Inflammatory Components of Qin Jin Hua Tan Tang by a Multivariate Statistical Analysis Approach for Spectrum-Effect Relationships: F. Duan, et al.; J. Anal. Methods Chem. 2021, 6348979 (2021), Abstract
- Bcl-3 promotes TNF-induced hepatocyte apoptosis by regulating the deubiquitination of RIP1: Y. Hu, et al.; Cell Death Differ. , (2021), Abstract
- The Aging of Adipocytes Increases Expression of Pro-Inflammatory Cytokines Chronologically: Ahmed, B., Si, H., et al.; Metabolites 11, (2021), Abstract
- RIPK1 dephosphorylation and kinase activation by PPP1R3G/PP1γ promote apoptosis and necroptosis: Du, J., Xiang, Y., et al.; Nat. Commun. 12, 7067 (2021), Reactant(s): Mouse, Abstract
- Artemisia iwayomogi (Dowijigi) inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppressing the NF-κB signaling pathway: Kim, S. M., Vetrivel, P., et al.; Exp. Ther. Med. 19, 2161 (2020), Abstract
- Redox Control of IL-6-Mediated Dental Pulp Stem-Cell Differentiation on Alginate/Hydroxyapatite Biocomposites for Bone Ingrowth: S. Sancilio, et al.; Nanomaterials (Basel) 9, 1656 (2019), Abstract — Full Text
- Early-Life Stress in D2 Heterozygous Mice Promotes Autistic-like Behaviors through the Downregulation of the BDNF-TrkB Pathway in the Dorsal Striatum: Lee, Y., Han, P. L., et al.; Exp. Neurobiol. 28, 337 (2019), Abstract
- A diet enriched with curcumin promotes resilience to chronic social defeat stress: A.V. Aubry, et al.; Neuropsychopharmacology 44, 733 (2019), Abstract
- MANF regulates metabolic and immune homeostasis in ageing and protects against liver damage: P. Sousa-Victor, et al.; Nat. Metab. 1, 276 (2019), Application(s): ELISA using tissue extracts, Abstract
- Inflammatory mediators resulting from transglutaminase 2 expressed in mast cells contribute to the development of Parkinson’s disease in a mouse model: G.U. Hong, et al.; Toxicol. Appl. Pharmacol. 358, 10 (2018), Application(s): ELISA using supernatants prepared from tissue homogenates, Abstract
- APC loss in breast cancer leads to doxorubicin resistance via STAT3 activation: M.K. VanKlompenberg , et al.; Oncotarget 8, 102868 (2017), Abstract
- The metabolic ER stress sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesity: B. Shan, et al.; Nat. Immunol. 18, 519 (2017), Abstract
- CLOCK modulates survival and acute lung injury in mice with polymicrobial sepsis: C.Y. Wang, et al.; Biochem. Biophys. Res. Commun. 478, 935 (2016), Application(s): Measurement of cytokine levels in serum and cell culture medium, Abstract
- The inhibiting effect of the Coptis chinensis polysaccharide on the type II diabetic mice: L. Cui, et al.; Biomed. Pharmacother. 81, 111 (2016), Application(s): ELISA using mouse blood samples, Abstract
- Sphingomyelin generated by sphingomyelin synthase 1 is involved in attachment and infection with Japanese encephalitis virus: M. Taniguchi, et al.; Sci. Rep. 6, 37829 (2016), Abstract — Full Text
- Activating transcription factor-3 induction is involved in the anti-inflammatory action of berberine in RAW264.7 murine macrophages: Y.A. Bae, et al.; Korean J. Physiol. Pharmacol. 20, 415 (2016), Application(s): ELISA using culture supernatants, Abstract — Full Text
- Ginseng marc-derived low-molecular weight oligosaccharide inhibits the growth of skin melanoma cells via activation of RAW264.7 cells: J.Y. Seo, et al.; Int. Immunopharmacol. 29, 344 (2015), Application(s): ELISA using culture supernatants, Abstract
- The immunostimulating activity of quercetin 3-O-xyloside in murine macrophages via activation of the ASK1/MAPK/NF-κB signaling pathway: J. Lee, et al.; Int. Immunopharmacol. 31, 88 (2015), Application(s): ELISA using cell culture supernatants, Abstract
- Mechanotransduction via TRPV4 regulates inflammation and differentiation in fetal mouse distal lung epithelial cells: P.S. Navak, et al.; Respir. Res. 16, 60 (2015), Abstract — Full Text
- Antioxidative, anti-inflammatory, and matrix metalloproteinase inhibitory activities of 20 (S)-ginsenoside Rg3 in cultured mammalian cell lines: Y.M. Shin, et al.; Mol. Biol. Rep. 40, 269 (2013), Application(s): EIA using culture supernatants from RAW264.7 macrophage cells, Abstract
- Reduced IL-10 Production in Fetal Type II Epithelial Cells Exposed to Mechanical Stretch Is Mediated via Activation of IL-6-SOCS3 Signaling Pathway: M.A. Hokenson, et al.; PLoS One 8, e59598 (2013), Abstract — Full Text
- Molecular mechanism of Jmjd3‐mediated interleukin‐6 gene regulation in endothelial cells underlying spinal cord injury: K. Lee, et al.; J. Neurochem. 122, 272 (2012), Application(s): ELISA using culture supernatants, Abstract
- Cilostazol enhances apoptosis of synovial cells from rheumatoid arthritis patients with inhibition of cytokine formation via Nrf2-linked heme oxygenase 1 induction: S.Y. Park, et al.; Arthritis Rheum. 62, 732 (2010), Application(s): EIA using mouse serum and cell culture supernatant, Abstract — Full Text
- Leptin improves pulmonary bacterial clearance and survival in ob/ob mice during pneumococcal pneumonia: A. Hsu, et al.; Clin. Exp. Immunol. 150, 332 (2007), Application(s): EIA using mouse tissue homogenate, Abstract — Full Text
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