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(±)-Verapamil . hydrochloride

ALX-550-306

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Ca²⁺ channel inhibitor

Blocks slow voltage-sensitive L-type Ca²⁺channels. Adrenergic antagonist. Inhibits platelet-activating factor and PMA-stimulated prostaglandin production in Kupffer cells. Induces apoptosis. In vitro resistance modifier in drug resistant human tumor cell lines.

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Product Details

Alternative Name	5-[(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropyl-valeronitrile . HCl
Appearance	White crystalline powder.
CAS	152-11-4
Couple Target	Calcium channel
Couple Type	Inhibitor
Formula	C₂₇H₃₈N₂O₄ . HCl
Identity	Determined by IR.
MI	14: 9950
MW	454.6 . 36.5
Purity	≥99% (HPLC)
RTECS	YV8320000
Solubility	Soluble in 100% ethanol (26mg/ml), methanol or water (83mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

In vitro assessment of the inhibitory effect of goreisan extract and its ingredients on the P-glycoprotein drug transporter and cytochrome P-450 metabolic enzymes: M. Takiyama, et al.; Xenobiotica 52, 511 (2022), Abstract
Targeting KRAS4A splicing through the RBM39/DCAF15 pathway inhibits cancer stem cells: W. C. Chen, et al.; Nat. Commun. 12, 4288 (2021), Abstract
Pharmacokinetic study of Ninjin’yoeito: Absorption and brain distribution of Ninjin’yoeito ingredients in mice: T. Matsumoto, et al.; J. Ethnopharmacol. 279, 114332 (2021), Abstract
Regulation of i>KRAS4A/B/i> splicing in cancer stem cells by the RBM39 splicing complex: Chen, W., To, M. D., et al.; bioRxiv , (2019)
Role of P-glycoprotein inhibitors in ceramide-based therapeutics for treatment of cancer: Morad, S. A. F., Davis, T. S., et al.; Biochem. Pharmacol. 130, 21 (2017), Abstract
Short-term exposure to L-type calcium channel blocker, verapamil, alters the expression pattern of calcium-binding proteins in the brain of goldfish, Carassius auratus: N.V. Palande, et al.; Comp. Biochem. Physiol. C: Tocicol. Pharmacol. 176-177, 31 (2015), Application(s): Cell culture in fish, Abstract
Overnutrition induces β-cell differentiation through prolonged activation of β-cells in zebrafish larvae: Li, M., Maddison, L. A., et al.; Am. J. Physiol. Endocrinol. Metab. 306, E799 (2014), Abstract
Angiotensin II mediates cell survival through upregulation and activation of the serum and glucocorticoid inducible kinase 1: Baskin, R., Sayeski, P. P., et al.; Cell. Signal. 24, 435 (2012), Abstract
Hyperthermia and verapamil inhibit the growth of human colon cancer xenografts in vivo through apoptosis: I.B. Shchepotin, et al.; Anticancer Res. 17, 2213 (1997), Abstract
Neuron degeneration induced by verapamil and attenuated by EGb761: L. Zhu, et al.; J. Basic Clin. Physiol. Pharmacol. 8, 301 (1997), Abstract

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Last modified: May 29, 2024

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(±)-Verapamil . hydrochloride

ALX-550-306

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