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Xestospongin C

BML-CA409

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IP3 receptor inhibitor

Xestonspongin C is a structurally novel marine alkaloid isolated from the Okinawan sponge Xestospongia sp. It is a potent, cell-permeable inhibitor of IP3 receptor-mediated Ca²⁺ release (IC₅₀ = 358 nM). However, since xestospongin C also inhibits voltage-dependent Ca²⁺ and K⁺ currents at concentrations similar to those which inhibit the IP3 receptor, it can only be regarded as a selective blocker of the IP3 receptor in permeabilized cells and not in cells with intact plasma membranes. Has vasodilatory properties.

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Product Details

Appearance	White to off-white powder.
CAS	88903-69-9
Couple Target	IP3 receptor
Couple Type	Inhibitor
Formula	C₂₈H₅₀N₂O₂
MW	446.7
Purity	≥90% (TLC)
Solubility	Soluble in DMSO or 100% ethanol at 2mM.
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light. Packaged under inert gas.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Luminal H2O2 promotes ER Ca2+ dysregulation and toxicity of palmitate in insulin-secreting INS-1E cells: S. Sharifi, et al.; FASEB J. 37, e22685 (2023), Abstract
The endoplasmic reticulum, not the pH gradient, drives calcium refilling of lysosomes: Garrity, A. G., Wang, W., et al.; Elife 5, (2016), Abstract
Layer-specific potentiation of network GABAergic inhibition in the CA1 area of the hippocampus: Colavita, M., Terral, G., et al.; Sci. Rep. 6, 28454 (2016), Abstract
Type 1 inositol (1,4,5)-trisphosphate receptor activates ryanodine receptor 1 to mediate calcium spark signaling in adult mammalian skeletal muscle: Tjondrokoesoemo, A., Li, N., et al.; J. Biol. Chem. 288, 2103 (2013), Abstract
Optogenetic probing and manipulation of the calyx-type presynaptic terminal in the embryonic chick ciliary ganglion: Egawa, R., Hososhima, S., et al.; PLoS One 8, e59179 (2013), Abstract
Activation of muscarinic M3 receptors inhibits large-conductance voltage- and Ca2+-activated K+ channels in rat urinary bladder smooth muscle cells: Parajuli, S. P., Petkov, G. V., et al.; Am. J. Physiol. Cell Physiol. 305, C207 (2013), Abstract
Pituitary adenylate cyclase-activating polypeptide induces postsynaptically expressed potentiation in the intra-amygdala circuit: Cho, J. H., Zushida, K., et al.; J. Neurosci. 32, 14165 (2012), Abstract
Induction of Ca²+-driven apoptosis in chronic lymphocytic leukemia cells by peptide-mediated disruption of Bcl-2-IP3 receptor interaction: Zhong, F., Harr, M. W., et al.; Blood 117, 2924 (2011), Abstract
Air bubble contact with endothelial cells in vitro induces calcium influx and IP3-dependent release of calcium stores: Sobolewski, P., Kandel, J., et al.; Am. J. Physiol. Cell Physiol. 301, C679 (2011), Abstract
Xestospongin C empties the ER calcium store but does not inhibit InsP3-induced Ca2+ release in cultured dorsal root ganglia neurones: N. Solovyova, et al.; Cell Calcium 21, 49 (2002), Abstract

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Xestospongin C

BML-CA409

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