Cannabinoid receptor agonist
High affinity cannabinoid receptor (CB) agonist (Ki=62.3nM and 3.3nM at the human cloned CB1 and CB2 receptors, respectively). Potent analgesic in a rat model of neuropathic pain. Activates p42 and p44 MAP kinase via a receptor-mediated signaling.
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Product Details
Alternative Name |
(R)-(+)-[2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenylmethanone . mesylate |
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Appearance |
White to off-white solid. |
CAS |
131543-23-2 |
Couple Target |
Cannabinoid receptor, MAPK |
Couple Type |
Activator, Ligand |
Formula |
C27H26N2O3 . CH3SO3H |
MW |
522.6 |
Purity |
≥98% (HPLC) |
Solubility |
Soluble in DMSO; insoluble in water. |
Technical Info / Product Notes |
WIN-55,212-2 is a controlled substance in some countries and may require an import/export license from the local authorities depending on the country of import. Orders for this product will incur an administrative fee to cover license expenses. Please inquire for additional information. |
Handling & Storage
Use/Stability |
As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
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Long Term Storage |
-20°C |
Shipping |
Ambient Temperature |
Regulatory Status |
RUO – Research Use Only |
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- Cannabinoid functions in the amygdala contribute to conditioned fear memory in streptozotocin-induced diabetic mice: Interaction with glutamatergic functions: H. Ikeda, et al.; Exp. Neurol. 269, 233 (2015), Application(s): Injection into mice, Abstract
- Glucose concentration in culture medium affects mRNA expression of TRPV1 and CB1 receptors and changes capsaicin toxicity in PC12 cells: Mohammadi-Farani, A., Ghazi-Khansari, M., et al.; Iran J. Basic. Med. Sci. 17, 673 (2014), Abstract
- Immunoregulation of a viral model of multiple sclerosis using the synthetic cannabinoid R+WIN55,212: J.L. Croxford & S.D. Miller; J. Clin. Invest. 111, 1231 (2003), Abstract
- Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation: I. Galve-Roperh, et al.; Nat. Med. 6, 313 (2000), Abstract
- An analgesia circuit activated by cannabinoids: I.D. Meng, et al.; Nature 395, 6700 (1998), Abstract
- The analgesic effects of R(+)-WIN 55,212-2 mesylate, a high affinity cannabinoid agonist, in a rat model of neuropathic pain: U. Herzberg, et al.; Neurosci. Lett. 221, 157 (1997), Abstract
- Rat brain cannabinoid receptor modulates N-type Ca2+ channels in a neuronal expression system: X. Pan, et al.; Mol. Pharmacol. 49, 707 (1996), Abstract
- Inhibition of long-term potentiation in rat hippocampal slices by anandamide and WIN55212-2: reversal by SR141716 A, a selective antagonist of CB1 cannabinoid receptors: J.P. Terranova, et al.; Naunyn-Schmiedeberg’s Arch. Pharmacol. 352, 576 (1995), Abstract
- Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors: C.C. Felder, et al.; Mol. Pharmacol. 48, 443 (1995), Abstract
- Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1: M. Bouaboula, et al.; Biochem. J. 312, 637 (1995), Abstract
- (+)-WIN 55,212-2, a novel cannabinoid receptor agonist, exerts antidystonic effects in mutant dystonic hamsters: A. Richter & W. Loscher; Eur. J. Pharmacol. 264, 371 (1994), Abstract
- Conformationally restrained analogues of pravadoline: nanomolar potent, enantioselective, (aminoalkyl)indole agonists of the cannabinoid receptor: T.E. D’Ambra, et al.; J. Med. Chem. 35, 124 (1992), Abstract
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Last modified: May 29, 2024
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