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WIN-55,212-2

BML-CR105

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Cannabinoid receptor agonist

High affinity cannabinoid receptor (CB) agonist (K_i=62.3nM and 3.3nM at the human cloned CB₁ and CB₂ receptors, respectively). Potent analgesic in a rat model of neuropathic pain. Activates p42 and p44 MAP kinase via a receptor-mediated signaling.

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Product Details

Alternative Name	(R)-(+)-[2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenylmethanone . mesylate
Appearance	White to off-white solid.
CAS	131543-23-2
Couple Target	Cannabinoid receptor, MAPK
Couple Type	Activator, Ligand
Formula	C₂₇H₂₆N₂O₃ . CH₃SO₃H
MW	522.6
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO; insoluble in water.
Technical Info / Product Notes	WIN-55,212-2 is a controlled substance in some countries and may require an import/export license from the local authorities depending on the country of import. Orders for this product will incur an administrative fee to cover license expenses. Please inquire for additional information.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Cannabinoid functions in the amygdala contribute to conditioned fear memory in streptozotocin-induced diabetic mice: Interaction with glutamatergic functions: H. Ikeda, et al.; Exp. Neurol. 269, 233 (2015), Application(s): Injection into mice, Abstract
Glucose concentration in culture medium affects mRNA expression of TRPV1 and CB1 receptors and changes capsaicin toxicity in PC12 cells: Mohammadi-Farani, A., Ghazi-Khansari, M., et al.; Iran J. Basic. Med. Sci. 17, 673 (2014), Abstract
Immunoregulation of a viral model of multiple sclerosis using the synthetic cannabinoid R+WIN55,212: J.L. Croxford & S.D. Miller; J. Clin. Invest. 111, 1231 (2003), Abstract
Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation: I. Galve-Roperh, et al.; Nat. Med. 6, 313 (2000), Abstract
An analgesia circuit activated by cannabinoids: I.D. Meng, et al.; Nature 395, 6700 (1998), Abstract
The analgesic effects of R(+)-WIN 55,212-2 mesylate, a high affinity cannabinoid agonist, in a rat model of neuropathic pain: U. Herzberg, et al.; Neurosci. Lett. 221, 157 (1997), Abstract
Rat brain cannabinoid receptor modulates N-type Ca2+ channels in a neuronal expression system: X. Pan, et al.; Mol. Pharmacol. 49, 707 (1996), Abstract
Inhibition of long-term potentiation in rat hippocampal slices by anandamide and WIN55212-2: reversal by SR141716 A, a selective antagonist of CB1 cannabinoid receptors: J.P. Terranova, et al.; Naunyn-Schmiedeberg’s Arch. Pharmacol. 352, 576 (1995), Abstract
Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors: C.C. Felder, et al.; Mol. Pharmacol. 48, 443 (1995), Abstract
Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1: M. Bouaboula, et al.; Biochem. J. 312, 637 (1995), Abstract

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WIN-55,212-2

BML-CR105

Product Details

Handling & Storage

Resources

Metabolism

Cellular Therapy

Cardiovascular Research

Drug Discovery

AMPIVIEW® RNA Probes

Immuno-Oncology

AMPIGENE® PCR Solutions

Bioprocess

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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