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Potent and specific inhibitor of phospholipase D1 (PLD1) in cellular (PLD1 IC50 = 11nM Calu-1 cells; PLD2 IC50 = 1800nM HEK293-gfpPLD2 cells) and in vitro (hPLD1 IC50 = 46nM; hPLD2 IC50 = 933nM) assays. Significantly decreases invasive migration in breast cancer cell lines (MDA-231, 4T1 and PMT).
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RUO – Research Use Only |
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