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VHR dual specificity phosphatase (human), (recombinant)

BML-SE333

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Dual specificity phosphatases (DUSPs) are members of the superfamily of protein tyrosine phosphatases. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation.

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VHR dual specificity phosphatase (human), (recombinant) SDS-PAGE — SDS-PAGE Analysis: Lane 1: MW Marker, Lane 2: 1 µg, Lane 3: 2 µg VHR dual-specificity phosphatase

Product Details

Alternative Name	Dual specificity protein phosphatase 3, DUSP3
Application Notes	Useful for the study of VHR dual phosphatase kinetics and substrate specificity, and to dephosphorylate pSer/Thr and pTyr phosphorylated protein substrates.
Formulation	Liquid. In 50mM citrate, pH 6.0, containing 0.1M sodium chloride, 1mM EDTA and 1mM DTT.
MW	20.4 kDa
Purity	≥95% (SDS-PAGE)
Source	Produced in E. coli.
Specific Activity	11U/mg. One unit will hydrolyze 1µmol p-nitrophenyl phosphate (pNPP) per minute at pH 6.0 and 30°C. Reaction conditions are 50mM citrate, pH 6.0, 0.1M NaCl, 1mM EDTA and 1mM DTT, 10mM pNPP substrate. An increase in signal of 3 to 4 fold can be achieved by addition of base to a pH of approximately 9.0 at the end of an assay with pNPP.
UniProt ID	P51452

Handling & Storage

Handling	Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Protein tyrosine phosphatase 1B inhibitory properties of seco-cucurbitane triterpenes obtained from fruiting bodies of Russula lepida: W. Maarisit, et al.; J. Nat. Med. 71, 334 (2017), Abstract
Identification and evaluation of magnolol and chrysophanol as the principle protein tyrosine phosphatase-1B inhibitory compounds in a Kampo medicine, Masiningan: T. Onoda, et al.; J. Ethnopharmacol. 186, 84 (2016), Application(s): PTP assay, Abstract

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VHR dual specificity phosphatase (human), (recombinant)

BML-SE333

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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