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Veratridine

BML-NA125

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Na⁺ channel activator

A Na⁺ channel activator. Does not affect Na^+-Ca_²⁺ exchange. Veratridine acts at neurotoxin receptor site 2 and preferentially binds to activated Na⁺ channels causing persistent activation. It prevents inactivation and shifts activation to more negative potentials. Induces cell death in bovine chromaffin cells.

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Product Details

Appearance	White to yellow solid.
CAS	71-62-5
Couple Target	Sodium channel
Couple Type	Activator
Formula	C₃₆H₅₁NO₁₁
MW	673.8
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Short Term Storage	-20°C
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Modelling inflammation-induced peripheral sensitization in a dish-more complex than expected?: Li, Y., Lock, A., et al.; Pain 166, 1662 (2025), Abstract
Modelling inflammation-induced peripheral sensitization in a dish – more complex than expected?: Li, Y., Lock, A., et al.; bioRxiv , (2024)
Effects of veratrine and veratridine on oxygen consumption and electrical membrane potential of isolated rat skeletal muscle and liver mitochondria: E.M. Silva Freitas et al.; Toxicon 47, 780 (2006), Abstract
Depolarization preconditioning produces cytoprotection against veratridine-induced chromaffin cell death: C. Orozco, et al.; Eur. J. Pharmacol. 553, 28 (2006), Abstract
A high-capacity membrane potential FRET-based assay for NaV1.8 channels: C.J. Liu, et al.; Assay Drug Dev. Technol. 4, 37 (2006), Abstract
Excessive release of [3H] noradrenaline by veratridine and ischemia in spinal cord: Y. Sumiya et al.; Neurochem. Int. 39, 59 (2001), Abstract
Alteration of veratridine neurotoxicity in sympathetic neurons during development in vitro: T. Koike & T. Ninomiya; Neuroreport 11, 151 (2000), Abstract
Veratridine induces apoptotic death in bovine chromaffin cells through superoxide production: J. Jordan et al.; Br. J. Pharmacol. 130, 1496 (2000), Abstract
Veratridine triggers exocytosis in Paramecium cells by activating somatic Ca channels: H. Plattner et al.; J. Membr. Biol. 142, 229 (1994), Abstract
Effects of Ca2+ channel antagonists on chromaffin cell death and cytosolic Ca2+ oscillations induced by veratridine: R. Maroto et al.; Eur. J. Pharmacol. 270, 331 (1994), Abstract

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Veratridine

BML-NA125

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