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Trop-2 (tumor-associated calcium signal transducer 2) is a 46-48kDa cell surface glycoprotein that acts as a calcium signal transducer. The molecule is expressed at high levels in human throphoblasts and overexpressed on a large variety of human carcinomas (including breast, colon, lung and prostate cancers). As an example, Trop-2 is among the most highly overexpressed genes in primary ovarian serous papillary tumors compared to normal ovarian epithelium and in in colon tumors compared with normal mucosa. Trop-2 is homologous to Trop-1 and both are homologous to serum IGF-II-binding proteins. The specific role of Trop-2 in normal and tumor cells is not fully defined, but accumulating evidence suggests a regulatory role in the growth of carcinoma cells. Furthermore there is data supporting the hypothesis that Trop-2 is involved in tumor invasion and metastasis. Indeed, TROP2 is one of the cancer-related genes that correlates with biological aggressiveness and poor prognosis of colorectal cancer.
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Immunofluorescence staining of TROP-2 in NCI-N87 cells. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with TROP-2 monoclonal antibody (dilution ratio 1:60) at 4℃ overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-mouse IgG secondary antibody (green) and counterstained with DAPI (blue).Positive staining was localized to Cell membrane.
Flow cytometric analysis of human TROP2 expression on NCI-N87 cells. Cells were stained with purified anti-Human TROP2, then a FITC-conjugated secondary antibody. The histogram were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Immunochemical staining of TROP2 in human placenta with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). Positive staining was localized to membrane of cytotrophoblast.
Immunochemical staining of TROP2 in human mammary gland with mouse monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to membrane of alveolus epithelium.
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