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TIM-3 monoclonal antibody (1B10)

ENZ-ABS702

  • ENZ-ABS702-0100   —   100 µg
    $604.00

The immune checkpoint protein TIM3 is a member of the immunoglobulin superfamily and TIM family of proteins. It is a Th1-specific cell surface protein that regulates macrophage activation and negatively regulates Th1-mediated auto- and alloimmune responses, and is also highly expressed on regulatory T cells, monocytes, macrophages, and dendritic cells. TIM3 and PD-1 are co-expressed on most CD4 and CD8 T cells infiltrating solid tumors or in hematologic malignancy in mice. Blocking TIM3 in conjugation with a PD-1 blockade increases the functionality of exhausted T cells and synergizes with to inhibit tumor growth.

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Regulatory Status

RUO – Research Use Only