Home Shop Thy-1 (human):Fc (human), (recombinant)

Thy-1 (human):Fc (human), (recombinant)

ALX-522-091

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Human Thy-1 is a glycosyl phosphatidylinositol (GPI)- anchored glycoprotein of the immunoglobulin superfamily expressed in various cell types, particularly in cells of the neuronal system, activited microvascular endothelial cells, fibroblasts and blood stem cells. Thy-1 is involved in cell adhesion. Human Thy-1 interacts with the integrin αvβ3 (CD51/CD61) and Mac-1 (CD11b/CD18). In astrocytes, binding of Thy-1 to beta3-integrin promotes focal adhesion formation. Historical results have shown that human Thy-1 binds to human αvβ3 integrin.

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Thy-1 (human):Fc (human), (recombinant) SDS-PAGE — SDS-PAGE analysis of Prod. No. ALX-522-091: Lane 1: MW marker, Lane 2: 0.1, Lane 3: 0.5, Labe 4: 1 µg Thy-1 (human):Fc (human), (recombinant).

Product Details

Alternative Name	CD90
Concentration	1mg/ml after reconstitution.
Endotoxin Content	<0.1EU/µg purified protein (LAL test; Bio Whittaker).
Formulation	Lyophilized. Contains PBS.
Purity	≥90% (SDS-PAGE)
Reconstitution	Reconstitute with 50µl sterile distilled water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
Source	Produced in HEK 293 cells. The extracellular domain of human Thy-1 (aa 20-130) is fused to the Fc portion of human IgG1.
UniProt ID	P04216

Handling & Storage

Use/Stability	Stable for at least 6 months after receipt when stored at -20°C.
Handling	Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Short Term Storage	+4°C
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Soluble Thy-1 reverses lung fibrosis via its integrin-binding motif: Tan, C., Jiang, M., et al.; JCI Insight 4, (2019), Abstract
Effect of the GPI anchor of human Thy-1 on antibody recognition and function: J.E. Bradley, et al.; Lab. Invest. 93, 365 (2013), Abstract — Full Text
Thy-1-Integrin {alpha}vβ5 Interactions Inhibit Lung Fibroblast Contraction-induced Latent Transforming Growth Factor-β1 Activation and Myofibroblast Differentiation: Y. Zhou, et al.; J. Biol. Chem. 285, 22382 (2010), Abstract — Full Text

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Thy-1 (human):Fc (human), (recombinant)

ALX-522-091

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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