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TAP1 polyclonal antibody

ADI-CSA-620

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TAP1 and TAP2 are two structurally related subunits of the Transporter associated with antigen processing (TAP). The TAP complex is a member of the ATP binding cassette (ABC) family of transmembrane transporters. The TAP transporter is an essential component of the MHC class I antigen presentation pathway by binding peptides in its cytosolic part and subsequently translocating the peptides into the lumen of the endoplasmic reticulum where assembly of MHC class I and pepide takes place.

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TAP1 polyclonal antibody Western blot — Western blot analysis of TAP1, pAb (Prod. No. ADI-CSA-620): Lane 1: MW marker, Lane 2: A431 cell lysate Lane 3: HeLa cell lysate (Prod. No. ADI-LYC-HL100)

TAP1 polyclonal antibody Immunohistochemistry — IHC Analysis: Human tonsil tissue stained with TAP1, pAb at 1:100.

Product Details

Alternative Name	Transporter Associated with Antigen Processing 1
Application	IHC (PS), IP, WB
Application Notes	Detects a band of ~70kDa by Western blot.
Formulation	Liquid. Whole rabbit serum.
Host	Rabbit
Immunogen	Synthetic peptide corresponding to a portion of human TAP1 .
Recommendation Dilutions/Conditions	Immunoprecipitation (1:100)Western Blot (ECL, 1:1,000-1:4000)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.
Source	Purified from rabbit serum.
Species Reactivity	Human, Rat
UniProt ID	Q03518
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

HLA-G peptide preferences change in transformed cells: impact on the binding motif: A.A. Celik, et al.; Immunogenetics 70, 485 (2018), Reactant(s) Human, Abstract
Feasibility and Immune Response of WT1 Peptide Vaccination in Combination with OK-432 for Paediatric Solid Tumors: K. Hirabayashi, et al.; Anticancer Res. 38, 2227 (2018), Application(s): IHC / Reactant(s) Human, Abstract
WT1-pulsed Dendritic Cell Vaccine Combined with Chemotherapy for Resected Pancreatic Cancer in a Phase I Study: R. Yanagisawa, et al.; Anticancer Res. 38, 2217 (2018), Application(s): IHC / Reactant(s) Human, Abstract
Genetic defects of the IRF1-mediated major histocompatibility complex class I antigen presentation pathway occur prevalently in the JAK2 gene in non-small cell lung cancer: T. Shen, et al.; Oncotarget 8, 60975 (2017), Reactant(s) Human, Abstract
Position 156 influences the peptide repertoire and tapasin dependency of human leukocyte antigen B*44 allotypes: S. Badrinath, et al.; Haematologica 97, 98 (2012), Application(s): IP, WB / Reactant(s) Human, Abstract — Full Text
MHC class I/beta 2-microglobulin complexes associate with TAP transporters before peptide binding: P. Cresswell, et al.; Nature 368, 864 (1994), Application(s): IP using human samples, Abstract