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ST2 is a member of a superfamily containing the interleukin-1 receptor and the Toll-like receptors (TLRs). ST2 was originally identified as a protein whose production was stimulated by various proliferation inducing agents such as PDGF and FGF. Additionally, it has been shown to negatively regulate IL-1 receptor and Toll-like receptor (TLR) 4 signaling and to maintain endotoxin tolerance.
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Western blot analysis of ST2 in mouse kidney lysate with ST2 antibody at 1µg/ml in the presence (lane A) or absence (lane B) of 1µg blocking peptide.
Immunohistochemistry analysis of ST2 in mouse kidney tissue with ST2 antibody at 2µg/ml.
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RUO – Research Use Only |
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