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The Src homology 2 domain containing (Shc) adaptor protein links growth factor, cytokine, and antigen receptor stimulation to the Ras signaling pathway, and plays a critical role in insulin signaling, tumorigenesis, and hematopoietic cell growth and differentiation. Structurally, Shc is composed of an N-terminal phosphotyrosine binding (PTB) domain, a medial CH1 domain, and a C-terminal SH2 domain. Upon binding to activate cell-surface receptors, Shc is phosphorylated at three tyrosine residues (Tyr239, Tyr240, Tyr317) triggering recognition of Shc by SH2-containing proteins such as Grb2.
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Immunohistochemistry analysis of human hepatoma tissue with Shc mAb (11F6).
Immunofluorescent analysis (confocal) staining of V79 cells using Shc mAb (11F6) (green); nuclei are stained in blue pseudocolor using DRAQ5.
Western blot analysis of cancer cell lysates with Shc mAb (11F6); HeLa (1), HepG2 (2), HEK293 (3), SH-SY5Y (4), MDCK (5), PC12 (6), CMT93 (7), Neuro 2A (8), NIH-3T3 (9).
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RUO – Research Use Only |
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