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Insulin sensitizing agent
Potent insulin sensitizing agent. Peroxisome proliferator-activated receptor γ (PPAR-γ) agonist. Hepatotoxic. Antidiabetic.
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Product Details
| Appearance |
White to off-white solid. |
|---|---|
| CAS |
122320-73-4 |
| Couple Target |
PPAR |
| Couple Type |
Activator, Ligand |
| Formula |
C18H19N3O3S |
| MI |
14: 8265 |
| MW |
357.4 |
| Purity |
≥97% (HPLC) |
| Solubility |
Soluble in DMSO (>25mg/ml), 100% ethanol or methanol. |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. Stable for 2 years after receipt when stored at +4°C. Stock solutions are stable for up to 3 months when stored at -20°C. |
|---|---|
| Long Term Storage |
+4°C |
| Shipping |
Ambient Temperature |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Divergent effects of the antiretroviral drugs, dolutegravir, tenofovir alafenamide, and tenofovir disoproxil fumarate, on human adipocyte function: T. Q. López, et al.; Biochem. Pharmacol. 220, 116010 (2024), Abstract
- Liver ChREBP deficiency inhibits fructose-induced insulin resistance in pregnant mice and female offspring: Li, J., Zhang, S., et al.; EMBO Rep. 25, 2097 (2024), Abstract
- PPARγ phase separates with RXRα at PPREs to regulate target gene expression: Li, Z., Luo, L., et al.; Cell Discov. 8, 37 (2022), Abstract
- Differential effects of dolutegravir, bictegravir and raltegravir in adipokines and inflammation markers on human adipocytes: P. Domingo, et al.; Life Scienes 308, 120948 (2022), Abstract
- Mild intermittent hypoxia exposure induces metabolic and molecular adaptations in men with obesity: van Meijel, R. L. J., Vogel, M. A. A., et al.; Mol. Metab. 53, 101287 (2021), Abstract
- Role of respiratory uncoupling in drug-induced mitochondrial permeability transition: T. Sato, et al.; Toxicol. Appl. Pharmacol. 427, 115659 (2021), Abstract
- Circulating Levels of Soluble Dipeptidyl Peptidase-4 Are Dissociated from Inflammation and Induced by Enzymatic DPP4 Inhibition: Varin, E. M., Mulvihill, E. E., et al.; Cell Metab. 29, 320 (2019), Abstract
- Assessment of adipogenic, antioxidant, and anti-inflammatory properties of whole and whey bovine colostrum: Lee, A., Pontin, M. C. F., et al.; J. Dairy Sci. 102, 8614 (2019), Abstract
- Reciprocal Effects of Antiretroviral Drugs Used To Treat HIV Infection on the Fibroblast Growth Factor 21/β-Klotho System: Moure, R., Domingo, P., et al.; Antimicrob. Agents Chemother. 62, (2018), Abstract
- Seipin deficiency in mice causes loss of dopaminergic neurons via aggregation and phosphorylation of α-synuclein and neuroinflammation: Wang, L., Hong, J., et al.; Cell Death Dis. 9, 440 (2018), Abstract
- A PPAR-gamma agonist protects from radiation-induced intestinal toxicity: M. Mangoni, et al.; United European Gastroenterol. J. 5, 218 (2017), Application(s): Cell culture, Abstract — Full Text
- Fermented blueberry juice extract and its specific fractions have an anti-adipogenic effect in 3 T3-L1 cells: Sánchez-Villavicencio, M. L., Vinqvist-Tymchuk, M., et al.; BMC Complement. Altern. Med. 17, 24 (2017), Abstract
- Aldehyde dehydrogenase 1 a1 regulates energy metabolism in adipocytes from different species: Yang, K., Adin, C., et al.; Xenotransplantation 24, (2017), Abstract
- Serelaxin increases the antifibrotic action of rosiglitazone in a model of hepatic fibrosis: Bennett, R. G., Simpson, R. L., et al.; World J. Gastroenterol. 23, 3999 (2017), Abstract
- Neuronal seipin knockout facilitates Aβ-induced neuroinflammation and neurotoxicity via reduction of PPARγ in hippocampus of mouse: Qian, Y., Yin, J., et al.; J. Neuroinflammation 13, 145 (2016), Abstract
- Effects of alpha-lipoic acid on chemerin secretion in 3 T3-L1 and human adipocytes: P.L. Prieto-Hontoria, et al.; Biochim. Biophys. Acta 1861, 260 (2016), Application(s): Cell culture, Abstract
- Dietary component isorhamnetin is a PPARγ antagonist and ameliorates metabolic disorders induced by diet or leptin deficiency: Zhang, Y., Gu, M., et al.; Sci. Rep. 6, 19288 (2016), Abstract
- Activation of PPARγ Ameliorates Spatial Cognitive Deficits through Restoring Expression of AMPA Receptors in Seipin Knock-Out Mice: Zhou, L., Chen, T., et al.; J. Neurosci. 36, 1242 (2016), Abstract
- A combination of (+)-catechin and (-)-epicatechin underlies the in vitro adipogenic action of Labrador tea (Rhododendron groenlandicum), an antidiabetic medicinal plant of the Eastern James Bay Cree pharmacopeia: H.M. Eid, et al.; J. Ethnopharmacol. 178, 251 (2016), Application(s): Cell culture, Abstract
- Effect of intranasal rosiglitazone on airway inflammation and remodeling in a murine model of chronic asthma: H.Y. Lee, et al.; Korean J. Intern. Med. 31, 89 (2016), Application(s): Cell culture, Abstract — Full Text
- ECM microenvironment unlocks brown adipogenic potential of adult human bone marrow-derived MSCs: M.H. Lee, et al.; Sci. Rep. 6, 21173 (2016), Application(s): Cell culture, Abstract — Full Text
- Seipin knockout in mice impairs stem cell proliferation and progenitor cell differentiation in the adult hippocampal dentate gyrus via reduced levels of PPARγ: Li, G., Zhou, L., et al.; Dis. Model. Mech. 8, 1615 (2015), Abstract
- Adipogenic Activity of Wild Populations of Rhododendron groenlandicum, a Medicinal Shrub from the James Bay Cree Traditional Pharmacopeia: Rapinski, M., Musallam, L., et al.; Evid. Based Complement. Alternat. Med. 2015, 492458 (2015), Abstract
- Rosiglitzone Suppresses Angiotensin II-Induced Production of KLF5 and Cell Proliferation in Rat Vascular Smooth Muscle Cells: D. Gao, et al.; PLoS One 10, e0123724 (2015), Application(s): Cell Culture, Abstract — Full Text
- A Novel Peroxisome Proliferator-activated Receptor (PPAR)α Agonist and PPARγ Antagonist, Z-551, Ameliorates High-fat Diet-induced Obesity and Metabolic Disorders in Mice: Y. Shiomi, et al.; J. Biol. Chem. 290, 14567 (2015), Application(s): Cell Culture, Abstract — Full Text
- Expression of human and mouse adenine nucleotide translocase (ANT) isoform genes in adipogenesis: A. Gavaldà-Navarro, et al.; Int. J. Biochem. Cell. Biol. 64, 34 (2015), Application(s): Cell Culture, Abstract
- Activation and inhibition of transient receptor potential TRPM3-induced gene transcription: Lesch, A., Rubil, S., et al.; Br. J. Pharmacol. 171, 2645 (2014), Abstract
- Optimal protocol for the differentiation and metabolic analysis of human adipose stromal cells: Lee, M. J., Fried, S. K., et al.; Methods Enzymol. 538, 49 (2014), Abstract
- Berberine activates thermogenesis in white and brown adipose tissue: Zhang, Z., Zhang, H., et al.; Nat. Commun. 5, 5493 (2014), Abstract
- Insulin excites anorexigenic proopiomelanocortin neurons via activation of canonical transient receptor potential channels: Qiu, J., Zhang, C., et al.; Cell Metab. 19, 682 (2014), Abstract
- p53 is required for brown adipogenic differentiation and has a protective role against diet-induced obesity: Molchadsky, A., Ezra, O., et al.; Cell Death Differ. 20, 774 (2013), Abstract
- Modulation of paraoxonase 2 (PON2) in mouse brain by the polyphenol quercetin: a mechanism of neuroprotection?: Costa, L. G., Tait, L., et al.; Neurochem. Res. 38, 1809 (2013), Abstract
- Pharmacological manipulation of peroxisome proliferator-activated receptor γ (PPARγ) reveals a role for anti-oxidant protection in a model of Parkinson’s disease: Martin, H. L., Mounsey, R. B., et al.; Exp. Neurol. 235, 528 (2012), Abstract
- Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue: Nadra, K., Medard, J. J., et al.; Mol. Cell. Biol. 32, 4794 (2012), Abstract
- Activation of peroxisome proliferator-activated receptor δ inhibits human macrophage foam cell formation and the inflammatory response induced by very low-density lipoprotein: Bojic, L. A., Sawyez, C. G., et al.; Arterioscler. Thromb. Vasc. Biol. 32, 2919 (2012), Abstract
- Modulation of RAGE and the Downstream Targets of RAGE Signaling Cascades by Taurine in Lycium Barbarum (Goji Berry): Protection of Human Retinal Pigment Epithelial Barrier Function and its Potential Benefit in Diabetic Retinopathy: M.K. Song, et al.; J. Diabetes Metab. 2, 162 (2011), Application(s): Cell Culture, Full Text
- Long-chain acyl-CoA synthetase 4 modulates prostaglandin E₂ release from human arterial smooth muscle cells: Golej, D. L., Askari, B., et al.; J. Lipid Res. 52, 782 (2011), Abstract
- In vitro and in vivo therapeutic efficacy of the PPAR-γ agonist troglitazone in combination with cisplatin against malignant pleural mesothelioma cell growth: Hamaguchi, N., Hamada, H., et al.; Cancer Sci. 101, 1955 (2010), Abstract
- IL-10 mediates rosiglitazone-induced kidney protection in cisplatin nephrotoxicity: Kim, M. G., Yang, H. N., et al.; J. Korean. Med. Sci. 25, 557 (2010), Abstract
- Peroxisome proliferator-activated receptor-alpha control of lipid and glucose metabolism in human white adipocytes: Ribet, C., Montastier, E., et al.; Endocrinology 151, 123 (2010), Abstract
- The role of tanshinone IIA in the treatment of obesity through peroxisome proliferator-activated receptor gamma antagonism: Gong, Z., Huang, C., et al.; Endocrinology 150, 104 (2009), Abstract
- PPARgamma regulates the function of human dendritic cells primarily by altering lipid metabolism: Szatmari, I., Töröcsik, D., et al.; Blood 110, 3271 (2007), Abstract
- 15-Deoxy-Delta12,14-prostaglandin J(2) induces death receptor 5 expression through mRNA stabilization independently of PPARgamma and potentiates TRAIL-induced apoptosis: Nakata, S., Yoshida, T., et al.; Mol. Cancer Ther. 5, 1827 (2006), Abstract
- Protein thiol modification by 15-deoxy-Delta12,14-prostaglandin J2 addition in mesangial cells: role in the inhibition of pro-inflammatory genes: Sánchez-Gómez, F. J., Cernuda-Morollón, E., et al.; Mol. Pharmacol. 66, 1349 (2004), Abstract
- Rosiglitazone (Avandia): hepatic, cardiac and hematological reactions: M. McMorran & D. Vu; CMAJ 165, 82 (2001), Abstract
- A review of rosiglitazone in type 2 diabetes mellitus: A.L. Werner & M.T. Travaglini; Pharmacotherapy 21, 1082 (2001), (Review), Abstract
- Rosiglitazone: an agent from the thiazolidinedione class for the treatment of type 2 diabetes: A. Cheng-Lai & A. Levine; Heart Dis. 2, 326 (2000), (Review), Abstract
- Rosiglitazone in the treatment of type 2 diabetes mellitus: a critical review: J.M. Malinowski & S. Bolesta; Clin. Ther. 22, 1151 (2000), (Review), Abstract
- Rosiglitazone: J.A. Balfour & G.L. Plosker; Drugs 57, 921 (1999), (Review) , Abstract
- Differential effects of insulin-sensitizers troglitazone and rosiglitazone on ion currents in rat vascular myocytes: G.A. Knock, et al.; Eur. J. Pharmacol. 368, 103 (1999), Abstract
- Differential activity of rosiglitazone enantiomers at PPAR gamma: D.J. Parks, et al.; Bioorg. Med. Chem. Lett. 81, 3657 (1998), Abstract
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