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PDE inhibitor
Selective, cell permeable inhibitor of cAMP-specific phosphodiesterase (PDE IV, IC50=1 µM). A rolipram insensitive PDE IV subtype has been described.
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Product Details
| Alternative Name |
(±)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone |
|---|---|
| Appearance |
White to off-white solid. |
| CAS |
61413-54-5 |
| Couple Target |
PDE |
| Couple Type |
Inhibitor |
| Formula |
C16H21NO3 |
| MI |
14: 8251 |
| MW |
275.4 |
| Purity |
≥98% (TLC) |
| RTECS |
UY5749237 |
| Solubility |
Soluble in DMSO (25mg/ml, warm), 100% ethanol (25mg/ml, warm) or acetone. |
| Technical Info / Product Notes |
Note: Product is not sterile. |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. Stable for at least 5 year after receipt when stored at +20°C. Stock solutions are stable for up to 3 months at -20°C. |
|---|---|
| Long Term Storage |
Ambient |
| Shipping |
Ambient Temperature |
| Regulatory Status |
RUO – Research Use Only |
|---|
- De novo missense variants in the PP2A regulatory subunit PPP2R2B in a neurodevelopmental syndrome: potential links to mitochondrial dynamics and spinocerebellar ataxias: Sandal, P., Jong, C. J., et al.; Hum. Mol. Genet. 34, 193 (2025), Abstract
- Increased expression of phosphodiesterase 4 in activated hepatic stellate cells promotes cytoskeleton remodeling and cell migration: M. Elnagdy, et al.; J. Pathol. 261, 361 (2023), Abstract
- Rolipram Protects Mice from Gram-negative Bacterium Escherichia coli-induced Inflammation and Septic Shock: X. Lu, et al.; Sci. Rep. 10, 175 (2020), Abstract — Full Text
- Shifting the balance of autophagy and proteasome activation reduces proteotoxic cell death: a novel therapeutic approach for restoring photoreceptor homeostasis: Y. Qiu, et al.; Cell Death Dis. 10, 547 (2019), Abstract — Full Text
- Inhibition of Phosphodiesterase 4 by FCPR03 Alleviates Lipopolysaccharide-Induced Depressive-Like Behaviors in Mice: Involvement of p38 and JNK Signaling Pathways: H. Yu, et al.; Int. J Mol. Sci. 19, 513 (2018), Abstract
- Role of natriuretic peptide receptor 2-mediated signaling in meiotic arrest of zebrafish oocytes and its estrogen regulation through G protein-coupled estrogen receptor (Gper): Y. Pang & P. Thomas; Gen. Comp. Endocrinol. 265, 180 (2018), Abstract
- Pathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems: Balaji, V., Kaniyappan, S., et al.; Autophagy 14, 2139 (2018), Abstract
- Dysregulation of hepatic cAMP levels via altered Pde4b expression plays a critical role in alcohol-induced steatosis: Avila, D. V., Barker, D. F., et al.; J. Pathol. 240, 96 (2016), Abstract
- Cyclic AMP Mimics the Anti-ageing Effects of Calorie Restriction by Up-Regulating Sirtuin: Z. Wang, et al.; Sci. Rep. 5, 12012 (2015), Application(s): Cell Culture, Abstract — Full Text
- Inhibition of type 4 cyclic nucleotide phosphodiesterase blocks intracellular TLR signaling in chronic lymphocytic leukemia and normal hematopoietic cells: Tan, Y., Watkins, A. A., et al.; J. Immunol. 194, 101 (2015), Abstract
- Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases: Park, S. J., Ahmad, F., et al.; Cell 148, 421 (2012), Abstract
- Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors: F. Mullershausen, et al.; Nat. Chem. Biol. 5, 428 (2009), Abstract
- Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs: D.C. Underwood, et al.; J. Pharmacol. Exp. Ther. 270, 250 (1994), Abstract
- Bemoradan–a novel inhibitor of the rolipram-insensitive cyclic AMP phosphodiesterase from canine heart tissue: J.B. Moore, et al.; Biochem. Pharmacol. 42, 679 (1991), Abstract
- The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors: M.L. Reeves, et al.; Biochem. J. 241, 535 (1987), Abstract
- Stereospecific binding of the antidepressant rolipram to brain protein structures: H.H. Schneider, et al.; Eur. J. Pharmacol. 127, 105 (1986), Abstract
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