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Carcinogenesis inhibitor
Potent, selective inducer of phase II detoxification enzymes. Inhibits chemically induced mammary tumor formation in rats.
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Product Details
| Alternative Name |
L-Sulforaphane, (-)-1-Isothiocyanato-(4R)-(methylsulfinyl)butane |
|---|---|
| Appearance |
Slightly yellowish liquid. **Please note this product can be very difficult to see and may present as an almost invisible film. |
| CAS |
142825-10-3 |
| Formula |
C6H11NOS2 |
| MI |
14: 8962 |
| MW |
177.3 |
| Purity |
≥98% (UHPLC) |
| Solubility |
Soluble in methanol, 100% ethanol, DMSO or ethyl acetate. |
| Source |
Chiral natural product isolated from broccoli. |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. |
|---|---|
| Long Term Storage |
-20°C |
| Shipping |
Ambient Temperature |
| Regulatory Status |
RUO – Research Use Only |
|---|
- GSH Levels Serve As a Biological Redox Switch Regulating Sulforaphane-Induced Cell Fate in Human Lens Cells: T.P.N. Huynh, et al.; Invest. Ophthalmol. Vis. Sci. 62, 1167 (2021), Abstract
- Novel Insights into the Regulatory Role of Nuclear Factor (Erythroid-Derived 2)-Like 2 in Oxidative Stress and Inflammation of Human Fetal Membranes: Menon, R., Peltier, M. R., et al.; Int. J. Mol. Sci. 21, (2020), Abstract
- CRISPR/Cas9 genome-wide screening identifies KEAP1 as a sorafenib, lenvatinib, and regorafenib sensitivity gene in hepatocellular carcinoma: Zheng, A., Chevalier, N., et al.; Oncotarget 10, 7058 (2019), Abstract
- The ciliary protein RPGRIP1L governs autophagy independently of its proteasome-regulating function at the ciliary base in mouse embryonic fibroblasts: Struchtrup, A., Wiegering, A., et al.; Autophagy 14, 567 (2018), Abstract
- Nrf2-Mediated Fibroblast Reprogramming Drives Cellular Senescence by Targeting the Matrisome: Hiebert, P., Wietecha, M. S., et al.; Dev. Cell 46, 145 (2018), Abstract
- Keap1-Independent Regulation of Nrf2 Activity by Protein Acetylation and a BET Bromodomain Protein: Chatterjee, N., Tian, M., et al.; PLoS Genet. 12, e1006072 (2016), Abstract
- The transition zone protein Rpgrip1l regulates proteasomal activity at the primary cilium: Gerhardt, C., Lier, J. M., et al.; J. Cell Biol. 210, 115 (2015), Abstract
- Benefits and risks of the hormetic effects of dietary isothiocyanates on cancer prevention: Bao, Y., Wang, W., et al.; PLoS One 9, e114764 (2014), Abstract
- Protective effect of sulforaphane against oxidative stress: Recent advances: C.E. Guerrero-Beltran, et al.; Exp. Toxicol. Pathol. 64, 503 (2012), Abstract
- Photothrombosis-induced infarction of the mouse cerebral cortex is not affected by the Nrf2-activator sulforaphane: Porritt, M. J., Andersson, H. C., et al.; PLoS One 7, e41090 (2012), Abstract
- Phytochemicals Resveratrol and Sulforaphane as Potential Agents for Enhancing the Anti-Tumor Activities of Conventional Cancer Therapies: B.M. Kaminski, et al.; Curr. Pharm. Biotechnol. 13, 137 (2012), Abstract
- The natural chemopreventive phytochemical R-sulforaphane is a far more potent inducer of the carcinogen-detoxifying enzyme systems in rat liver and lung than the S-isomer: A.F. Abdull Razis, et al.; Int. J. Cancer 128, 2775 (2011), Abstract
- Sulforaphane induces cytotoxicity and lysosome- and mitochondria-dependent cell death in colon cancer cells with deleted p53: E. Rudolf & M. Cervinka; Toxicol. In Vitro 25, 1302 (2011), Abstract
- Repeated transient sulforaphane stimulation in astrocytes leads to prolonged Nrf2-mediated gene expression and protection from superoxide-induced damage: P. Bergstrom, et al.; Neuropharmacology 60, 343 (2011), Abstract
- Sulforaphane induces DNA single strand breaks in cultured human cells: P. Sestili, et al.; Mutat. Res. 689, 65 (2010), Abstract
- Sulforaphane targets pancreatic tumor-initiating cells by NF-{kappa}B-induced anti-apoptotic signaling: G. Kallifatidis, et al.; Gut 58, 949 (2009), Abstract
- Reprogramming of keratin biosynthesis by sulforaphane restores skin integrity in epidermolysis bullosa simplex: M.L. Kerns, et al.; PNAS 104, 14460 (2007), Abstract
- Induction of phase 2 genes by sulforaphane protects retinal pigment epithelial cells against photooxidative damage: X. Gao & P. Talalay; PNAS 101, 10446 (2004), Abstract
- A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase: M.C. Myzak ,et al.; Cancer Res. 64, 5767 (2004), Abstract — Full Text
- Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors: J.W. Fahey, et al.; PNAS 99, 7610 (2002), Abstract — Full Text
- Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates: Y. Zhang, et al.; PNAS 91, 3147 (1994), Abstract — Full Text
- A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure: Y. Zhang, et al.; PNAS 89, 2399 (1992), Abstract — Full Text
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