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[pTyr1322]Insulin receptor monoclonal antibody (21G12)

ADI-905-646

  • ADI-905-646-100   —   100 µg
    $572.00

The Insulin Receptor (InsR) is a heterodimeric receptor tyrosine kinase with an extracellular alpha-chain, a transmembrane domain and an intracellular beta-chain. InsR is activated upon binding of the peptide hormone insulin, leading to autophosphorylation of tyrosine residues 1146, 1150, and 1151 in the activation loop of the beta-chain. Additional autophosphorylation sites such as tyrosine residues 960, 972, 1316, and 1322 regulate the assembly of signal transduction complexes.

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Regulatory Status

RUO – Research Use Only